prochlorperazine edisylate

Adult Dosing .

Dosage forms:  INJ: 5 mg per mL

nausea/vomiting, severe

[5-10 mg IM q3-4h]

Max: 10 mg/dose, 40 mg/day; Alt: 2.5-10 mg IV q3-5h; Info: D/C if ANC <1000; consider D/C if unexplained decr. in WBC

nausea/vomiting prevention, postop

[5-10 mg IM x1]

Max: 10 mg/dose, 40 mg/day; Alt: 5-10 mg IV x1; Info: give IM dose 1-2h or IV dose 15-30min before induction; may repeat q30min x1; D/C if ANC <1000; consider D/C if unexplained decr. in WBC

schizophrenia

[10-20 mg IM q4-6h]

Start: 10-20 mg IM q1-4h for acute, severe agitation; Max: 150 mg/day; Info: may incr. 5-10 mg q2-3 days; D/C if ANC <1000; consider D/C if unexplained decr. in WBC

nausea/vomiting, migraine-assoc. (off-label)

[10 mg IM/IV x1]

nausea/vomiting prevention, chemo-related (off-label)

[10 mg IV x1 before chemo]

Info: for pts receiving low-emetogenic parenteral chemo; may repeat 10 mg IV qd for multi-day chemo; D/C if ANC <1000; consider D/C if unexplained decr. in WBC; search 'CINV' for epocrates Chemo-Induced Nausea & Vomiting in Adults decision tool

refractory nausea/vomiting, chemo-related (off-label)

[10 mg IV q6h]

Info: D/C if ANC <1000; consider D/C if unexplained decr. in WBC; search 'CINV' for epocrates Chemo-Induced Nausea & Vomiting in Adults decision tool

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]

Peds Dosing .

Dosage forms:  INJ: 5 mg per mL

nausea/vomiting, severe

[2 yo and older, 9-14 kg]

Dose: 0.1-0.13 mg/kg/dose IM q8-12h; Max: 7.5 mg/day; Info: D/C if ANC <1000; consider D/C if unexplained decr. in WBC

[2 yo and older, 14-18 kg]

Dose: 0.1-0.13 mg/kg/dose IM q8-12h; Max: 10 mg/day; Info: D/C if ANC <1000; consider D/C if unexplained decr. in WBC

[2 yo and older, 18-39 kg]

Dose: 0.1-0.13 mg/kg/dose IM q8-12h; Max: 15 mg/day; Info: D/C if ANC <1000; consider D/C if unexplained decr. in WBC

[2 yo and older, >39 kg]

Dose: 0.1-0.13 mg/kg/dose IM q8-12h; Max: 20 mg/day; Info: D/C if ANC <1000; consider D/C if unexplained decr. in WBC

schizophrenia

[2-5 yo]

Dose: 0.1-0.13 mg/kg/dose IM q8-12h; Max: 10 mg/day on 1st day then 20 mg/day; Info: D/C if ANC <1000; consider D/C if unexplained decr. in WBC

[6-11 yo]

Dose: 0.1-0.13 mg/kg/dose IM q8-12h; Max: 10 mg/day on 1st day then 25 mg/day; Info: D/C if ANC <1000; consider D/C if unexplained decr. in WBC

[12 yo and older]

see Adult Dosing

nausea/vomiting, migraine-assoc. (off-label)

[2 yo and older, >9 kg]

Dose: 0.15 mg/kg/dose IV x1; Max: 10 mg/dose

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]