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Aptivus
tipranavir
Black Box Warnings .
Hepatotoxicity
clinical hepatitis and hepatic decompensation (incl. fatal) in pts on tipranavir + ritonavir 200 mg; incr. risk if chronic HBV or HCV co-infection
Intracranial Hemorrhage
fatal and non-fatal intracranial hemorrhage reported in pts on tipranavir + ritonavir 200 mg; other medical conditions or medications may have caused or contributed; no abnormal pattern of coagulation parameters observed, no routine monitoring recommended; caution in pts at incr. bleeding risk
Adult Dosing .
Dosage forms: CAP: 250 mg
HIV infection
- [500 mg PO bid]
- Info: for tx-experienced pts w/ multi-protease inhibitor resistance; not recommended per DHHS guidelines; give w/ ritonavir 200 mg PO bid; D/C if AST/ALT 5-10x ULN and total bilirubin >2.5x ULN in asymptomatic pts; do not open cap; give w/ food
renal dosing
- [no adjustment]
- renal impairment: no adjustment
- HD/PD: no adjustment; no supplement
hepatic dosing
- [see below]
- Child-Pugh Class B or C: contraindicated
Peds Dosing .
- Dosage forms: CAP: 250 mg
HIV infection
- [>36 kg]
- Dose: 500 mg PO bid; Info: for tx-experienced pts w/ multi-protease inhibitor resistance; not recommended per DHHS guidelines; give w/ ritonavir 200 mg PO bid; D/C if AST/ALT 5-10x ULN and total bilirubin >2.5x ULN in asymptomatic pts; do not open cap; give w/ food
renal dosing
- [no adjustment]
- renal impairment: no adjustment
- HD/PD: no adjustment; no supplement
hepatic dosing
- [see below]
- Child-Pugh Class B or C: contraindicated