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sunitinib
generic
Black Box Warnings .
Hepatotoxicity
may be severe or fatal; monitor LFTs at baseline, then during each cycle; interrupt, reduce, or D/C tx as recommended
Adult Dosing .
Dosage forms: CAP: 12.5 mg, 25 mg, 37.5 mg, 50 mg
Special Note
- [uses, dosing may vary]
- Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing including toxicity-related dose adjustments; D/C >3wk before elective surgery or invasive dental procedure, restart >14 days after major surgery when wound fully healed
gastrointestinal stromal tumor, previously treated
- [50 mg PO qd on days 1-28 of 42-day cycle]
- Info: for patients with disease progression on or intolerance to imatinib
renal cell CA
- [adjuvant tx]
- Dose: 50 mg PO qd on days 1-28 of 42-day cycle; Info: for patients with high recurrence risk; give x9 cycles
- [advanced disease]
- Dose: 50 mg PO qd on days 1-28 of 42-day cycle
pancreatic neuroendocrine tumors, unresectable locally advanced or metastatic
- [37.5 mg PO qd]
- Info: for patients with progressive, well-differentiated disease
renal dosing
- [see below]
- renal impairment: no adjustment
- HD: no initial dose adjustment, consider incr. subsequent doses up to 2x usual dose; PD: not defined
hepatic dosing
- [see below]
- Child-Pugh Class A or B: no adjustment; Child-Pugh Class C: not defined
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.