darunavir

Adult Dosing .

Dosage forms:  TAB: 600 mg, 800 mg

HIV infection

[tx-naive patients]

Dose: 800 mg PO qd; Info: give with ritonavir 100 mg PO qd or cobicistat 150 mg PO qd; give with food

[tx-experienced patients without darunavir resistance substitution]

Dose: 800 mg PO qd; Info: give with ritonavir 100 mg PO qd or cobicistat 150 mg PO qd; give with food

[tx-experienced patients with darunavir resistance substitution or unknown baseline resistance]

Dose: 600 mg PO bid; Info: give with ritonavir 100 mg PO bid; give with food

[pregnant patients]

Dose: 600 mg PO bid; Info: give with ritonavir 100 mg PO bid; may consider continuing 800 mg PO qd with ritonavir 100 mg PO qd in virally suppressed patients stable on regimen before pregnancy if compliance or tolerability concerns; give with food

HIV post-exposure prophylaxis (off-label)

[non-pregnant patients]

Dose: 800 mg PO qd; Info: give with ritonavir 100 mg PO qd; part of multi-drug regimen; refer to HIV Post-Exposure Prophylaxis, Occupational and HIV Post-Exposure Prophylaxis, Nonoccupational tables; give with food

[pregnant patients]

Dose: 600 mg PO bid; Info: give with ritonavir 100 mg PO bid; Info: part of multi-drug regimen; refer to HIV Post-Exposure Prophylaxis, Nonoccupational table; give with food

renal dosing

[no adjustment]

renal impairment: no adjustment

HD/PD: no adjustment; no supplement

hepatic dosing

[see below]

Child-Pugh Class C: avoid use

Peds Dosing .

Dosage forms:  TAB: 600 mg, 800 mg

HIV infection, tx-naive or tx-experienced without darunavir resistance substitution

[3-17 yo, 20-29.9 kg]

Dose: 375 mg PO bid; Info; give with ritonavir 100 mg PO bid; give with food; use 75 mg and 150 mg tab or oral suspension, not available as generic; see brand

[3-17 yo, 30-39.9 kg]

Dose: 450 mg PO bid; Info; give with ritonavir 100 mg PO bid; give with food; use 150 mg tab or oral suspension, not available as generic; see brand

[3-11 yo, >40 kg]

Dose: 600 mg PO bid; Info; give with ritonavir 100 mg PO bid; give with food

[12-17 yo, >40 kg]

Dose: 800 mg PO qd; Info; give with ritonavir 100 mg PO qd or cobicistat 150 mg PO qd; give with food

HIV infection, tx-experienced with darunavir resistance substitution

[3-17 yo, 20-29.9 kg]

Dose: 375 mg PO bid; Info: give with ritonavir 100 mg PO bid; give with food; use 75 mg and 150 mg tab or oral suspension, not available as generic; see brand

[3-17 yo, 30-39.9 kg]

Dose: 450 mg PO bid; Info: give with ritonavir 100 mg PO bid; give with food; use 150 mg tab or oral suspension, not available as generic; see brand

[3-17 yo, >40 kg]

Dose: 600 mg PO bid; Info: give with ritonavir 100 mg PO bid; give with food

HIV post-exposure prophylaxis, nonoccupational (off-label)

[3-17 yo, 10-14 kg]

Dose: 35 mg/kg/dose PO qd; Info: give with ritonavir 7 mg/kg/dose PO qd; part of multi-drug regimen; refer to HIV Post-Exposure Prophylaxis, Nonoccupational table; give with food; use 75 mg and 150 mg tab or oral suspension, not available as generic; see brand

[3-17 yo, 15-29.9 kg]

Dose: 600 mg PO qd; Info: give with ritonavir 100 mg PO qd; part of multi-drug regimen; refer to HIV Post-Exposure Prophylaxis, Nonoccupational table; give with food; use 75 mg and 150 mg tab or oral suspension, not available as generic; see brand

[3-17 yo, 30-39.9 kg]

Dose: 675 mg PO qd; Info: give with ritonavir 100 mg PO qd; part of multi-drug regimen; refer to HIV Post-Exposure Prophylaxis, Nonoccupational table; give with food; use 150 mg tab or oral suspension, not available as generic; see brand

[3-17 yo, >40 kg]

Dose: 800 mg PO qd; Info: give with ritonavir 100 mg PO qd; part of multi-drug regimen; refer to HIV Post-Exposure Prophylaxis, Nonoccupational table; give with food

[pregnant patients]

Dose: 600 mg PO bid; Info: give with ritonavir 100 mg PO bid; Info: part of multi-drug regimen; refer to HIV Post-Exposure Prophylaxis, Nonoccupational table; give with food

renal dosing

[no adjustment]

renal impairment: no adjustment

HD/PD: no adjustment; no supplement

hepatic dosing

[see below]

Child-Pugh Class C: avoid use