Prezista

Adult Dosing .

Dosage forms:  TAB: 75 mg, 150 mg, 600 mg, 800 mg; SUSP: 100 mg per mL

HIV infection

[tx-naive pts]

Dose: 800 mg PO qd; Info: give w/ ritonavir 100 mg PO qd or cobicistat 150 mg PO qd; give w/ food

[tx-experienced pts w/o darunavir resistance substitution]

Dose: 800 mg PO qd; Info: give w/ ritonavir 100 mg PO qd or cobicistat 150 mg PO qd; give w/ food

[tx-experienced pts w/ darunavir resistance substitution or unknown baseline resistance]

Dose: 600 mg PO bid; Info: give w/ ritonavir 100 mg PO bid; give w/ food

[pregnant pts]

Dose: 600 mg PO bid w/ ritonavir 100 mg PO bid; Info: may consider cont. 800 mg PO qd w/ ritonavir 100 mg PO qd in virally suppressed pts stable on regimen before pregnancy if compliance or tolerability concerns; give w/ food

HIV post-exposure prophylaxis (off-label)

[800 mg PO qd]

Info: give w/ ritonavir 100 mg PO qd; part of multi-drug regimen; refer to HIV Post-Exposure Prophylaxis, Occupational and HIV Post-Exposure Prophylaxis, Nonoccupational tables; give w/ food

renal dosing

[no adjustment]

renal impairment: no adjustment

HD/PD: no adjustment; no supplement

hepatic dosing

[see below]

severe impairment: avoid use

Peds Dosing .

Dosage forms:  TAB: 75 mg, 150 mg, 600 mg, 800 mg; SUSP: 100 mg per mL

HIV infection, tx-naive or tx-experienced w/o darunavir resistance substitution

[3-17 yo, 20-29.9 kg]

Dose: 375 mg PO bid; Info; give w/ ritonavir 100 mg PO bid; give w/ food

[3-17 yo, 30-39.9 kg]

Dose: 450 mg PO bid; Info; give w/ ritonavir 100 mg PO bid; give w/ food

[3-11 yo, >40 kg]

Dose: 600 mg PO bid; Info; give w/ ritonavir 100 mg PO bid; give w/ food

[12-17 yo, >40 kg]

Dose: 800 mg PO qd; Info; give w/ ritonavir 100 mg PO qd or cobicistat 150 mg PO qd; give w/ food

HIV infection, tx-experienced w/ darunavir resistance substitution

[3-17 yo, 20-29.9 kg]

Dose: 375 mg PO bid; Info: give w/ ritonavir 100 mg PO bid; give w/ food

[3-17 yo, 30-39.9 kg]

Dose: 450 mg PO bid; Info: give w/ ritonavir 100 mg PO bid; give w/ food

[3-17 yo, >40 kg]

Dose: 600 mg PO bid; Info: give w/ ritonavir 100 mg PO bid; give w/ food

HIV post-exposure prophylaxis, nonoccupational (off-label)

[3-17 yo, 20-29.9 kg]

Dose: 375 mg PO bid; Info: give w/ ritonavir 100 mg PO bid; part of multi-drug regimen; refer to HIV Post-Exposure Prophylaxis, Nonoccupational table; give w/ food

[3-17 yo, 30-39.9 kg]

Dose: 450 mg PO bid; Info: give w/ ritonavir 100 mg PO bid; part of multi-drug regimen; refer to HIV Post-Exposure Prophylaxis, Nonoccupational table; give w/ food

[3-17 yo, >40 kg]

Dose: 600 mg PO bid; Info: give w/ ritonavir 100 mg PO bid; part of multi-drug regimen; refer to HIV Post-Exposure Prophylaxis, Nonoccupational table; give w/ food

renal dosing

[no adjustment]

renal impairment: no adjustment

HD/PD: no adjustment; no supplement

hepatic dosing

[see below]

severe impairment: avoid use