dasatinib

Adult Dosing .

Dosage forms:  TAB: 20 mg, 50 mg, 70 mg, 80 mg, 100 mg, 140 mg

Special Note

[uses, dosing may vary]

Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing incl. toxicity-related dose adjustments

Ph-positive CML

[chronic phase, newly diagnosed]

Dose: 100 mg PO qd; Info: may incr. dose to 140 mg PO qd if hematologic or cytogenetic response not achieved; do not cut/crush/chew tab

[chronic phase, resistant or intolerant dz]

Dose: 100 mg PO qd; Info: may incr. dose to 140 mg PO qd if hematologic or cytogenetic response not achieved; do not cut/crush/chew tab

[accelerated phase or blast phase, resistant or intolerant dz]

Dose: 140 mg PO qd; Info: may incr. dose to 180 mg PO qd if hematologic or cytogenetic response not achieved; do not cut/crush/chew tab

Ph-positive ALL, relapsed or refractory

[140 mg PO qd]

Info: may incr. dose to 180 mg PO qd if hematologic or cytogenetic response not achieved; do not cut/crush/chew tab

renal dosing

[see below]

renal impairment: no adjustment

HD/PD: not defined

hepatic dosing

[not defined]

Peds Dosing .

Peds dosing is currently unavailable or not applicable for this drug.