JAMA Netw Open

ACE inhibitors, ARBs linked to better outcomes after nonlobar brain bleeds

February 7, 2025

Study details: This cohort study examined the association between the initiation of different classes of antihypertensive medications during hospitalization and functional outcomes at 90 days in patients with nonlobar intracerebral hemorrhage (ICH). The study included patients admitted with nonlobar ICH and tracked their medication use and recovery outcomes.

Results: Among the nonlobar ICH cohort, 37.7% of participants initiated ACE inhibitors (ACEIs) or angiotensin receptor blockers (ARBs), 38.8% started on β-blockers, 46.6% on calcium channel blockers, and 16.7% on thiazide diuretics. At 90 days, 44.6% of patients achieved a favorable functional outcome. Initiation of ACEIs or ARBs was significantly associated with higher odds of favorable functional outcomes (adjusted OR 1.49; 95% confidence interval, 1.08-2.05; P = 0.01). No other antihypertensive class demonstrated a significant association with functional outcomes.

Clinical impact: ACEIs or ARBs may offer a class-specific benefit in improving functional outcomes after nonlobar ICH, potentially guiding antihypertensive therapy choices in this patient population.

Source:

Ridha M, et al. (2025, February 3). JAMA Netw Open. Antihypertensive Medication Class and Functional Outcomes After Nonlobar Intracerebral Hemorrhage. https://pubmed.ncbi.nlm.nih.gov/39899295/