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pioglitazone/ glimepiride
generic
Black Box Warnings .
Congestive Heart Failure
thiazolidinediones cause or exacerbate CHF; observe patients closely after tx initiation or dose incr. for signs/symptoms including excessive, rapid wt gain, dyspnea, and/or edema; manage CHF based on current care standards if signs/symptoms develop and consider D/C or dose reduction; contraindicated in patients with NYHA Class III-IV CHF and not recommended in patients with symptomatic CHF
Adult Dosing .
Dosage forms: TAB: 30 mg/2 mg, 30 mg/4 mg
diabetes mellitus, type 2
- [1 tab PO qam]
- Info: give with food
renal dosing
- [see below]
- renal impairment: avoid use, dose adjustment not possible with fixed-dose combo
- HD/PD: avoid use, dose adjustment not possible with fixed-dose combo
hepatic dosing
- [see below]
- hepatic impairment: avoid use for initial tx, dose adjustment not possible with fixed-dose combo
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.