Elixophyllin

Adult Dosing .

Dosage forms:  SOL: 80 mg per 15 mL

COPD, maintenance tx

[individualize dose PO q6-8h]

Start: 300 mg/day PO divided q6-8h x3 days, then may incr. to 400 mg/day PO divided q6-8h x3 days, then may incr. to 600 mg/day PO divided q6-8h; Info: see pkg insert for dose adjustments based on serum levels; in rapid metabolizers divide total daily dose more frequently; max 400 mg/day if serum level monitoring not feasible or reduced clearance risk factors, incl. elderly, hepatic impairment, CHF, fever, sepsis w/ multi-organ failure, shock, 3rd trimester of pregnancy, and hypothyroidism

asthma, maintenance tx

[individualize dose PO q6-8h]

Start: 300 mg/day PO divided q6-8h x3 days, then may incr. to 400 mg/day PO divided q6-8h x3 days, then may incr. to 600 mg/day PO divided q6-8h; Info: see pkg insert for dose adjustments based on serum levels; in rapid metabolizers divide total daily dose more frequently; max 400 mg/day if serum level monitoring not feasible or reduced clearance risk factors, incl. elderly, hepatic impairment, CHF, fever, sepsis w/ multi-organ failure, shock, 3rd trimester of pregnancy, and hypothyroidism

renal dosing

[see below]

renal impairment: no adjustment

HD/PD: not defined

hepatic dosing

[adjust dose amount]

hepatic impairment: decr. usual dose, amount not defined

Peds Dosing .

Dosage forms:  SOL: 80 mg per 15 mL

asthma, maintenance tx

[premature neonates, <24 days old]

Dose: individualize dose PO q12h; Start: 1 mg/kg/dose PO q12h; Info: see pkg insert for dose adjustments based on serum levels; use IBW to calculate dose

[premature neonates, 24 days old and older]

Dose: individualize dose PO q12h; Start: 1.5 mg/kg/dose PO q12h; Info: see pkg insert for dose adjustments based on serum levels; use IBW to calculate dose

[full term neonates or infants up to 26 wk old]

Dose: individualize dose PO q8h; Start: ((0.2 x age [wk]) + 5) x wt [kg] = mg/day PO divided q8h; Info: see pkg insert for dose adjustments based on serum levels; use IBW to calculate dose

[26-52 wk old]

Dose: individualize dose PO q6h; Start: ((0.2 x age [wk]) + 5) x wt [kg] = mg/day PO divided q6h; Info: see pkg insert for dose adjustments based on serum levels; use IBW to calculate dose

[1-15 yo, <45 kg]

Dose: individualize dose PO q4-6h; Start: 12-14 mg/kg/day up to 300 mg PO divided q4-6h x3 days, then may incr. to 16 mg/kg/day up to 400 mg PO divided q4-6h x3 days, then may incr. to 20 mg/kg/day up to 600 mg PO divided q4-6h; Info: see pkg insert for dose adjustments based on serum levels; use IBW to calculate dose; in rapid metabolizers divide total daily dose more frequently; max 16 mg/kg/day up to 400 mg/day if serum level monitoring not feasible or reduced clearance risk factors, incl. hepatic impairment, CHF, fever, sepsis w/ multi-organ failure, shock, 3rd trimester of pregnancy, and hypothyroidism

[1 yo and older, >45 kg]

Dose: individualize dose PO q6-8h; Start: 300 mg/day PO divided q6-8h x3 days, then may incr. to 400 mg/day PO divided q6-8h x3 days, then may incr. to 600 mg/day PO divided q6-8h; Info: see pkg insert for dose adjustments based on serum levels; in rapid metabolizers divide total daily dose more frequently; max 400 mg/day if serum level monitoring not feasible or reduced clearance risk factors, incl. hepatic impairment, CHF, fever, sepsis w/ multi-organ failure, shock, 3rd trimester of pregnancy, and hypothyroidism

apnea of prematurity (off-label)

[3-6 mg/kg/day PO divided q6-8h]

Start: 5 mg/kg/dose PO x1; Info: adjust dose based on serum levels

renal dosing

[0-3 mo]

renal impairment: decr. usual dose, amount not defined

HD/PD: not defined

[>3 mo]

renal impairment: no adjustment

HD/PD: not defined

hepatic dosing

[adjust dose amount]

hepatic impairment: decr. usual dose, amount not defined