Ixempra

Adult Dosing .

Dosage forms:  INJ

Special Note

[uses, dosing may vary]

Info: refer to institution protocols and pkg insert prior to prescribing for uses, premeds, and dosing incl. toxicity-related dose adjustments; for pts >2.2 m^2, cap wt at 2.2 m^2 for dose calculations

breast CA, locally advanced or metastatic

[40 mg/m^2/dose IV x1 on day 1 of 21-day cycle]

Max: 88 mg/dose; Info: use w/ capecitabine in pts whose dz is resistant to an anthracycline and a taxane, or use as monotherapy in pts whose dz is resistant to an anthracycline, a taxane, and capecitabine

renal dosing

[see below]

CrCl >30: no adjustment; CrCl <30: not defined

HD/PD: not defined

hepatic dosing

[capecitabine combo tx]

AST or ALT >2.5x ULN or bilirubin >ULN: contraindicated

[monotherapy]

AST and ALT <2.5x ULN and bilirubin < ULN: no adjustment; AST and ALT <10x ULN and bilirubin <1.5x ULN: give 32 mg/m^2/dose; AST and ALT <10x ULN and bilirubin 1.5-3x ULN: start 20 mg/m^2/dose, max 30 mg/m^2/dose; AST or ALT >10x ULN or bilirubin >3x ULN: avoid use

Peds Dosing .

Peds dosing is currently unavailable or not applicable for this drug.