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Lysodren
mitotane
Black Box Warnings .
Adrenal Crisis
occurs in setting of shock, severe trauma, or infection; may lead to death; D/C tx temporarily and give exogenous steroids if shock, severe trauma, or infection occurs or develops; monitor pts closely for infections; instruct pts to contact physician immediately if injury, infection or any concomitant illness occurs
Adult Dosing .
Dosage forms: TAB: 500 mg
Special Note
- [uses, dosing may vary]
- Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing incl. toxicity-related dose adjustments
adrenocortical carcinoma
- [individualize dose PO tid-qid]
- Start: 2-6 g/day PO divided tid-qid, then incr. dose incrementally as tolerated based on mitotane plasma levels; Info: for inoperable, functional, or nonfunctional dz; give w/ food; do not cut/crush/chew tab
renal dosing
- [see below]
- mild-moderate impairment: not defined, caution advised; severe impairment: avoid use
- HD/PD: not defined
hepatic dosing
- [see below]
- mild-moderate impairment: not defined, caution advised; severe impairment: avoid use
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.