Nplate

Adult Dosing .

Dosage forms:  INJ

ITP

[1-10 mcg/kg/dose SC qwk]

Start: 1 mcg/kg/dose SC qwk; Max: 10 mcg/kg/wk; Info: for pts who had insufficient response to corticosteroids, immunoglobulins, or splenectomy; see pkg insert for dose adjustments based on Plt response; use lowest effective dose to achieve/maintain Plt >50,000; hold if Plt >400,000; D/C if no incr. in Plt after 4wk at max dose; use ABW to calculate dose

hematopoietic syndrome of acute radiation syndrome

[10 mcg/kg/dose SC x1]

Start: ASAP after suspected or confirmed exposure to radiation doses >2 Gy

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]

Peds Dosing .

Dosage forms:  INJ

ITP

[1 yo and older]

Dose: 1-10 mcg/kg/dose SC qwk; Start: 1 mcg/kg/dose SC qwk, adjust dose by 1 mcg/kg based on Plt response and body wt changes, see pkg insert; Max: 10 mcg/kg/wk; Info: for pts w/ ITP for at least 6mo who had insufficient response to corticosteroids, immunoglobulins, or splenectomy; use lowest effective dose to achieve/maintain Plt >50,000; hold if Plt >400,000; D/C if no incr. in Plt after 4wk at max dose; use ABW to calculate dose

hematopoietic syndrome of acute radiation syndrome

[10 mcg/kg/dose SC x1]

Start: ASAP after suspected or confirmed exposure to radiation doses >2 Gy

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]