Select a medication above to begin.
everolimus (oncologic)
generic
Adult Dosing .
Dosage forms: TAB: 2.5 mg, 5 mg, 7.5 mg, 10 mg; DISPERSE TAB: 2 mg, 3 mg, 5 mg
Special Note
- [equivalency or interchangeability info]
- Info: tab not interchangeable w/ disperse tab; do not substitute on a mg to mg basis; use tab and disperse tab only for their approved indications
- [uses, dosing may vary]
- Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing incl. toxicity-related dose adjustments; D/C >1wk before elective surgery, restart >2wk after major surgery when wound fully healed
hormone receptor-positive HER2-negative breast CA, advanced
- [tab form]
- Dose: 10 mg PO qd; Info: for postmenopausal pts who have failed letrozole or anastrozole; use w/ exemestane; give consistently w/ food or empty stomach; do not cut/crush/chew tab; do not use disperse tab
neuroendocrine tumors, progressive
- [tab form]
- Dose: 10 mg PO qd; Info: for pts w/ unresectable, locally advanced or metastatic tumors of pancreatic, GI, or lung origin; give consistently w/ food or empty stomach; do not cut/crush/chew tab; do not use disperse tab
renal cell CA, advanced
- [tab form, monotherapy]
- Dose: 10 mg PO qd; Info: for pts who have failed sunitinib or sorafenib; give consistently w/ food or empty stomach; do not cut/crush/chew tab; do not use disperse tab
- [tab form, combo w/ lenvatinib]
- Dose: 5 mg PO qd; Info: for pts who have received 1 prior antiangiogenic tx; give consistently w/ food or empty stomach; do not cut/crush/chew tab; do not use disperse tab
renal angiomyolipoma, tuberous sclerosis complex-associated
- [tab form]
- Dose: 10 mg PO qd; Info: for pts not requiring immediate surgery; give consistently w/ food or on empty stomach; do not cut/crush/chew tab; do not use disperse tab
subependymal giant cell astrocytoma, tuberous sclerosis complex-associated
- [tab form]
- Dose: individualize dose PO qd; Start: 4.5 mg/m^2/dose PO qd; Info: for pts who cannot be curatively resected; may adjust dose by up to 5 mg/day q1-2wk based on trough levels; give consistently w/ food or on empty stomach; do not cut/crush/chew tab; do not combine tab and disperse tab to achieve the total dose
- [disperse tab form]
- Dose: individualize dose PO qd; Start: 4.5 mg/m^2/dose PO qd; Info: for pts who cannot be curatively resected; may adjust dose by up to 5 mg/day q1-2wk based on trough levels; give consistently w/ food or on empty stomach; use disperse tab for oral susp if unable to swallow tab whole; do not combine tab and disperse tab to achieve the total dose
partial seizures, tuberous sclerosis complex-associated
- [disperse tab form]
- Dose: individualize dose PO qd; Start: 5 mg/m^2/dose PO qd; Info: for adjunctive tx; may adjust dose by up to 5 mg/day q1-2wk based on trough levels; give consistently w/ food or on empty stomach; use only disperse tab
renal dosing
- [see below]
- renal impairment: no adjustment
- HD/PD: not defined
hepatic dosing
- [tuberous sclerosis complex-associated subependymal giant cell astrocytoma or partial seizures]
- Child-Pugh Class C: start 2.5 mg/m^2/dose qd
- [all other indications]
- Child-Pugh Class A: 7.5 mg qd, may decr. dose to 5 mg qd if not tolerated; Child-Pugh Class B: 5 mg qd, may decr. dose to 2.5 mg qd if not tolerated; Child-Pugh Class C: 2.5 mg qd, weigh risk/benefit
Peds Dosing .
- Dosage forms: TAB: 2.5 mg, 5 mg, 7.5 mg, 10 mg; DISPERSE TAB: 2 mg, 3 mg, 5 mg
Special Note
- [equivalency or interchangeability info]
- Info: tab not interchangeable w/ disperse tab; do not substitute on a mg to mg basis; use tab and disperse tab only for their approved indications
- [uses, dosing may vary]
- Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing incl. toxicity-related dose adjustments; D/C >1wk before elective surgery, restart >2wk after major surgery when wound fully healed
subependymal giant cell astrocytoma, tuberous sclerosis complex-associated
- [tab form, 1 yo and older]
- Dose: individualize dose PO qd; Start: 4.5 mg/m^2/dose PO qd; Info: for pts who cannot be curatively resected; may adjust dose by up to 5 mg/day q1-2wk based on trough levels; give consistently w/ food or on empty stomach; do not cut/crush/chew tab; do not combine tab and disperse tab to achieve the total dose
- [disperse tab form, 1 yo and older]
- Dose: individualize dose PO qd; Start: 4.5 mg/m^2/dose PO qd; Info: for pts who cannot be curatively resected; may adjust dose by up to 5 mg/day q1-2wk based on trough levels; give consistently w/ food or on empty stomach; use disperse tab for oral susp if unable to swallow tab whole; do not combine tab and disperse tab to achieve the total dose
partial seizures, tuberous sclerosis complex-associated
- [disperse tab form, 2 yo and older]
- Dose: individualize dose PO qd; Start: 5 mg/m^2/dose PO qd; Info: for adjunctive tx; may adjust dose by up to 5 mg/day q1-2wk based on trough levels; give consistently w/ food or on empty stomach; use only disperse tab
renal dosing
- [see below]
- renal impairment: no adjustment
- HD/PD: not defined
hepatic dosing
- [adjust dose amount]
- Child-Pugh Class C: start 2.5 mg/m^2/dose qd