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WinRho SDF
Rho(D) immune globulin
Black Box Warnings .
Intravascular Hemolysis in Immune Thrombocytopenic Purpura (ITP)
cases of intravascular hemolysis (IVH) leading to severe anemia, multi-system organ failure, ARDS, renal insufficiency or failure, DIC, and death have been reported in ITP pts treated w/ intravenous Rho(D) immune globulin products; monitor ITP pts closely in health care setting for at least 8h after admin; obtain dipstick urinalysis at baseline, 2h and 4h after admin. and prior to end of monitoring period; alert pts to s/sx of IVH incl. back pain, rigors, fever, or hematuria; if IVH present or suspected, obtain post-tx tests incl. Hgb, haptoglobin, LDH and bilirubin; use Rh-negative RBC if transfusion required post-tx
Adult Dosing .
Dosage forms: INJ
Special Note
- [strength clarification]
- Info: doses expressed in mcg; 1 mcg = 5 international units
Rh-incompatible pregnancy
- [routine prophylaxis]
- Dose: 300 mcg IM/IV x1 at 28 wk gestation, then 120 mcg IM/IV x1 w/in 72h of delivery
- [fetomaternal hemorrhage risk, <34 wk gestation]
- Dose: 300 mcg IM/IV x1 immediately following obstetrical complication or invasive procedure
- [fetomaternal hemorrhage risk, >34 wk gestation]
- Dose: 120 mcg IM/IV x1 w/in 72h of obstetrical complication or invasive procedure
- [excessive fetomaternal hemorrhage, IM route]
- Dose: 1200 mcg IM q12h until total dose administered; Start: w/in 72h of exposure; Info: total dose = 24 mcg/mL of RBC exposure or 12 mcg/mL of whole blood exposure
- [excessive fetomaternal hemorrhage, IV route]
- Dose: 600 mcg IV q8h until total dose administered; Start: w/in 72h of exposure; Info: total dose = 18 mcg/mL of RBC exposure or 9 mcg/mL of whole blood exposure
Rh-incompatible transfusion
- [IM route]
- Dose: 1200 mcg IM q12h until total dose administered; Start: w/in 72h of exposure; Info: total dose = 24 mcg/mL of RBC exposure or 12 mcg/mL of whole blood exposure
- [IV route]
- Dose: 600 mcg IV q8h until total dose administered; Start: w/in 72h of exposure; Info: total dose = 18 mcg/mL of RBC exposure or 9 mcg/mL of whole blood exposure
idiopathic thrombocytopenic purpura
- [initial dose, Hgb 8-10]
- Dose: 25-40 mcg/kg/dose IV x1; Info: for Rh-positive, non-splenectomized pts; may give as two divided doses on separate days; if no response, may give subsequent dose
- [initial dose, Hgb >10]
- Dose: 50 mcg/kg/dose IV x1; Info: for Rh-positive, non-splenectomized pts; may give as two divided doses on separate days; if no response, may give subsequent dose
- [subsequent dose, Hgb 8-10]
- Dose: 25-40 mcg/kg/dose IV prn; Info: adjust frequency based on clinical response
- [subsequent dose, Hgb >10]
- Dose: 50-60 mcg/kg/dose IV prn; Info: adjust frequency based on clinical response
renal dosing
- [IM route]
- renal impairment: not defined
- HD/PD: not defined
- [IV route]
- renal impairment: not defined, caution advised; Info: use minimum infusion rate practicable
- HD/PD: not defined
hepatic dosing
- [not defined]
Peds Dosing .
- Dosage forms: INJ
Special Note
- [strength clarification]
- Info: doses expressed in mcg; 1 mcg = 5 international units
idiopathic thrombocytopenic purpura
- [initial dose, Hgb 8-10]
- Dose: 25-40 mcg/kg/dose IV x1; Info: for Rh-positive, non-splenectomized pts; may give as two divided doses on separate days; if no response, may give subsequent dose
- [initial dose, Hgb >10]
- Dose: 50 mcg/kg/dose IV x1; Info: for Rh-positive, non-splenectomized pts; may give as two divided doses on separate days; if no response, may give subsequent dose
- [subsequent dose, Hgb 8-10]
- Dose: 25-40 mcg/kg/dose IV prn; Info: adjust frequency based on clinical response
- [subsequent dose, Hgb >10]
- Dose: 50-60 mcg/kg/dose IV prn; Info: adjust frequency based on clinical response
renal dosing
- [see below]
- renal impairment: not defined, caution advised; Info: use minimum infusion rate practicable
- HD/PD: not defined
hepatic dosing
- [not defined]