Photofrin

Adult Dosing .

Dosage forms:  INJ

esophageal CA, palliative tx

[2 mg/kg/dose IV x1]

Info: to complete 2-step photodynamic tx (PDT) use laser light 40-50h post-injection, may repeat laser light 96-120h post-injection; may repeat 2-step PDT after >30 days, up to 3 courses total

endobronchial non-small cell lung CA

[microinvasive disease]

Dose: 2 mg/kg/dose IV x1; Info: for patients ineligible for surgery or XRT; to complete 2-step photodynamic tx (PDT) use laser light 40-50h post-injection, may repeat laser light 96-120h post-injection; may repeat 2-step PDT after >30 days, up to 3 courses total

[palliative tx]

Dose: 2 mg/kg/dose IV x1; Info: to complete 2-step photodynamic tx (PDT) use laser light 40-50h post-injection, may repeat laser light 96-120h post-injection; may repeat 2-step PDT after >30 days, up to 3 courses total

Barrett esophagus dysplasia, high-grade

[2 mg/kg/dose IV x1]

Info: for patients ineligible for esophagectomy; to complete 2-step photodynamic tx (PDT) use laser light 40-50h post-injection, may repeat laser light 96-120h post-injection; may repeat 2-step PDT after >90 days, up to 3 courses total

renal dosing

[see below]

renal impairment: not defined, caution advised

HD/PD: not defined, caution advised

hepatic dosing

[see below]

hepatic impairment: not defined, caution advised

Peds Dosing .

Peds dosing is currently unavailable or not applicable for this drug.