Select a medication above to begin.
ganciclovir
generic
Black Box Warnings .
Hematologic Toxicity
granulocytopenia, anemia, thrombocytopenia, and pancytopenia reported
Fertility Impairment
may cause temporary or permanent spermatogenesis inhibition in males and fertility suppression in females based on animal data and limited human data
Fetal Toxicity
potential to cause birth defects based on animal data
Mutagenesis/Carcinogenesis
potential to cause cancers based on animal data
Adult Dosing .
Dosage forms: INJ
CMV prophylaxis, solid organ transplant
- [induction tx]
- Dose: 5 mg/kg/dose IV q12h x7-14 days
- [maintenance tx]
- Dose: 5 mg/kg/dose IV q24h; Alt: 6 mg/kg IV 5x/wk
CMV retinitis, immunocompromised pts
- [induction tx]
- Dose: 5 mg/kg/dose IV q12h x14-21 days; Info: not 1st-line agent
- [maintenance tx]
- Dose: 5 mg/kg/dose IV q24h; Alt: 6 mg/kg IV 5x/wk; Info: not 1st-line agent
renal dosing
- [induction tx]
- CrCl 50-69: 2.5 mg/kg/dose q12h; CrCl 25-49: 2.5 mg/kg/dose q24h; CrCl 10-24: 1.25 mg/kg/dose q24h; CrCl <10: 1.25 mg/kg/dose 3x/wk
- HD: max 1.25 mg/kg/dose 3x/wk after dialysis; consider supplement if next maint. dose not due right after dialysis; PD: 1.25 mg/kg/dose 3x/wk; supplement not defined
- [maintenance tx]
- CrCl 50-69: 2.5 mg/kg/dose q24h; CrCl 25-49: 1.25 mg/kg/dose q24h; CrCl 10-24: 0.625 mg/kg/dose q24h; CrCl <10: 0.625 mg/kg/dose 3x/wk
- HD: max 0.625 mg/kg/dose 3x/wk after dialysis; consider supplement if next maint. dose not due right after dialysis; PD: 0.625 mg/kg/dose 3x/wk; supplement not defined
hepatic dosing
- [not defined]
Peds Dosing .
- Dosage forms: INJ
CMV prophylaxis, solid organ transplant (off-label)
- [induction tx, 2 yo and older]
- Dose: 5 mg/kg/dose IV q12h x7-14 days
- [maintenance tx, 2 yo and older]
- Dose: 5 mg/kg/dose IV q24h; Alt: 6 mg/kg/dose IV 5x/wk
CMV prophylaxis, HIV-assoc. (off-label)
- [1 mo and older]
- Dose: 5 mg/kg/dose IV q24h
CMV infection (off-label)
- [induction tx, 3 mo and older]
- Dose: 5 mg/kg/dose IV q12h x14-21 days; Info: may incr. dose to 7.5 mg/kg/dose IV q12h
- [maintenance tx, 3 mo and older]
- Dose: 5 mg/kg/dose IV q24h; Alt: 6 mg/kg/dose IV 5x/wk
CMV infection, congenital (off-label)
- [<1 mo]
- Dose: 6 mg/kg/dose IV q12h x6wk
renal dosing
- [induction tx]
- CrCl 50-69: 2.5 mg/kg/dose q12h; CrCl 25-49: 2.5 mg/kg/dose q24h; CrCl 10-24: 1.25 mg/kg/dose q24h; CrCl <10: 1.25 mg/kg/dose 3x/wk
- HD: 1.25 mg/kg/dose 3x/wk after dialysis; consider supplement if next maint. dose not due right after dialysis; PD: 1.25 mg/kg/dose 3x/wk; supplement not defined
- [maintenance tx]
- CrCl 50-69: 2.5 mg/kg/dose q24h; CrCl 25-49: 1.25 mg/kg/dose q24h; CrCl 10-24: 0.625 mg/kg/dose q24h; CrCl <10: 0.625 mg/kg/dose 3x/wk
- HD: 0.625 mg/kg/dose 3x/wk after dialysis; consider supplement if next maint. dose not due right after dialysis; PD: 0.625 mg/kg/dose 3x/wk; supplement not defined
hepatic dosing
- [not defined]