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Black Box Warnings .
Thrombotic and Thromboembolic Events
have been reported, particularly following high doses or in pts w/ thrombotic risk factors; monitor for s/sx of thromboembolism
Adult Dosing .
Dosage forms: INJ
Brand Name Changed in US
- [previously Feiba NF]
hemophilia A or B w/ inhibitors
- [bleeding episode]
- Dose: 50-100 units/kg/dose IV q6-12h until hemostasis; Max: 100 units/kg/dose up to 200 units/kg/day; Info: dose, duration varies by site/severity of bleeding, severity of deficiency
- [bleeding prophylaxis, surgery]
- Dose: 50-100 units/kg/dose IV x1 preop, then q6-12h until hemostasis; Max: 100 units/kg/dose up to 200 units/kg/day; Info: dose, duration varies by type of surgery, severity of deficiency
- [routine bleeding prophylaxis]
- Dose: 85 units/kg/dose IV qod
renal dosing
- [not defined]
- renal impairment: not defined
- HD/PD: not defined
hepatic dosing
- [not defined]
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.