Select a medication above to begin.
lurasidone
generic
Black Box Warnings .
Dementia-Related Psychosis
not approved for dementia-related psychosis; incr. mortality risk in elderly dementia patients on conventional or atypical antipsychotics; most deaths due to cardiovascular or infectious events; extent to which incr. mortality attributed to antipsychotic vs. some patient characteristic(s) not clear
Suicidality
incr. suicidality risk in children, adolescents, and young adults with major depressive or other psychiatric disorders; weigh risk vs. benefit; in short-term studies of antidepressants vs. placebo, suicidality risk not incr. in patients >24 yo, and risk decr. in patients 65 yo and older; depression and certain other psychiatric disorders themselves associated with incr. suicide risk; observe all patients for clinical worsening, suicidality, or unusual behavior changes; advise families and caregivers of need for close observation and communication with prescriber
Adult Dosing .
Dosage forms: TAB: 20 mg, 40 mg, 60 mg, 80 mg, 120 mg
schizophrenia
- [40-160 mg PO qd]
- Start: 40 mg PO qd; Max: 160 mg/day; Info: give with food containing >350 calories
bipolar I disorder, acute depressive
- [20-120 mg PO qd]
- Start: 20 mg PO qd; Max: 120 mg/day; Info: for monotherapy or valproate or lithium adjunct; doses >80 mg/day rarely more effective as monotherapy; give with food containing >350 calories
renal dosing
- [see below]
- CrCl <50: start 20 mg qd, max 80 mg/day
- HD/PD: not defined
hepatic dosing
- [adjust dose amount]
- Child-Pugh Class B: start 20 mg qd, max 80 mg/day; Class-Pugh Class C: start 20 mg qd, max 40 mg/day
Peds Dosing .
- Dosage forms: TAB: 20 mg, 40 mg, 60 mg, 80 mg
schizophrenia
- [13-17 yo]
- Dose: 40-80 mg PO qd; Start: 40 mg PO qd; Max: 80 mg/day; Info: give with food containing >350 calories
bipolar I disorder, acute depressive
- [10-17 yo]
- Dose: 20-80 mg PO qd; Start: 20 mg PO qd x1wk; Max: 80 mg/day; Info: for monotherapy; give with food containing >350 calories
renal dosing
- [see below]
- CrCl <50: start 20 mg qd, max 80 mg/day
- HD/PD: not defined
hepatic dosing
- [adjust dose amount]
- Child-Pugh Class B: start 20 mg qd, max 80 mg/day; Class-Pugh Class C: start 20 mg qd, max 40 mg/day