Bosulif

Adult Dosing .

Dosage forms:  CAP: 50 mg, 100 mg; TAB: 100 mg, 400 mg, 500 mg

Special Note

[uses, dosing may vary]

Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing incl. toxicity-related dose adjustments

Ph-positive CML

[chronic phase, newly diagnosed dz]

Dose: 400 mg PO qd; Max: 600 mg/day; Info: may incr. dose in 100 mg increments; give w/ food; do not cut/crush/chew tab

[chronic phase, resistant or tx-intolerant dz]

Dose: 500 mg PO qd; Max: 600 mg/day; Info: may incr. dose in 100 mg increments; give w/ food; do not cut/crush/chew tab

[accelerated phase or blast phase, resistant or tx-intolerant dz]

Dose: 500 mg PO qd; Max: 600 mg/day; Info: may incr. dose in 100 mg increments; give w/ food; do not cut/crush/chew tab

renal dosing

[newly diagnosed dz]

CrCl 30-50: 300 mg qd; CrCl <30: 200 mg qd

HD/PD: not defined

[resistant or tx-intolerant dz]

CrCl 30-50: 400 mg qd; CrCl <30: 300 mg qd

HD/PD: not defined

hepatic dosing

[adjust dose amount]

Child-Pugh Class A, B, or C: 200 mg qd

Peds Dosing .

Dosage forms:  CAP: 50 mg, 100 mg; TAB: 100 mg, 400 mg, 500 mg

Special Note

[uses, dosing may vary]

Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing incl. toxicity-related dose adjustments

Ph-positive CML, chronic phase

[newly diagnosed dz, 1 yo and older, BSA <0.55 m^2]

Dose: 150 mg PO qd; Info: may incr. dose in 50 mg increments up to 250 mg/day if insufficient response after 3mo; give w/ food; do not cut/crush/chew tab

[newly diagnosed dz, 1 yo and older, BSA 0.55-0.74 m^2]

Dose: 200 mg PO qd; Info: may incr. dose in 50 mg increments up to 300 mg/day if insufficient response after 3mo; give w/ food; do not cut/crush/chew tab

[newly diagnosed dz, 1 yo and older, BSA 0.75-0.89 m^2]

Dose: 250 mg PO qd; Info: may incr. dose in 50 mg increments up to 350 mg/day if insufficient response after 3mo; give w/ food; do not cut/crush/chew tab

[newly diagnosed dz, 1 yo and older, BSA 0.9-1.09 m^2]

Dose: 300 mg PO qd; Info: may incr. dose in 50 mg increments up to 400 mg/day if insufficient response after 3mo; give w/ food; do not cut/crush/chew tab

[newly diagnosed dz, 1 yo and older, BSA >1.1 m^2]

Dose: 400 mg PO qd; Max: 600 mg/day; Info: may incr. dose in 100 mg increments if insufficient response after 3mo; give w/ food; do not cut/crush/chew tab

[resistant or tx-intolerant dz, 1 yo and older, BSA <0.55 m^2]

Dose: 200 mg PO qd; Info: may incr. dose in 50 mg increments up to 300 mg/day if insufficient response after 3mo; give w/ food; do not cut/crush/chew tab

[resistant or tx-intolerant dz, 1 yo and older, BSA 0.55-0.62 m^2]

Dose: 250 mg PO qd; Info: may incr. dose in 50 mg increments up to 350 mg/day if insufficient response after 3mo; give w/ food; do not cut/crush/chew tab

[resistant or tx-intolerant dz, 1 yo and older, BSA 0.63-0.74 m^2]

Dose: 300 mg PO qd; Info: may incr. dose in 50 mg increments up to 400 mg/day if insufficient response after 3mo; give w/ food; do not cut/crush/chew tab

[resistant or tx-intolerant dz, 1 yo and older, BSA 0.75-0.89 m^2]

Dose: 350 mg PO qd; Info: may incr. dose in 50 mg increments up to 450 mg/day if insufficient response after 3mo; give w/ food; do not cut/crush/chew tab

[resistant or tx-intolerant dz, 1 yo and older, BSA 0.9-1.09 m^2]

Dose: 400 mg PO qd; Info: may incr. dose in 50 mg increments up to 500 mg/day if insufficient response after 3mo; give w/ food; do not cut/crush/chew tab

[resistant or tx-intolerant dz, 1 yo and older, BSA >1.1 m^2]

Dose: 500 mg PO qd; Max: 600 mg/day; Info: may incr. dose in 100 mg increments if insufficient response after 3mo; give w/ food; do not cut/crush/chew tab

renal dosing

[newly diagnosed dz, BSA <0.55 m^2]

CrCl <50: 100 mg qd

HD/PD: not defined

[newly diagnosed dz, BSA 0.55-0.74 m^2]

CrCl 30-50: 150 mg qd; CrCl <30: 100 mg qd

HD/PD: not defined

[newly diagnosed dz, BSA 0.75-0.89 m^2]

CrCl 30-50: 200 mg qd; CrCl <30: 150 mg qd

HD/PD: not defined

[newly diagnosed dz, BSA 0.9-1.09 m^2]

CrCl <50: 200 mg qd

HD/PD: not defined

[newly diagnosed dz, BSA >1.1 m^2]

CrCl 30-50: 300 mg qd; CrCl <30: 200 mg qd

HD/PD: not defined

[resistant or tx-intolerant dz, BSA <0.55 m^2]

CrCl 30-50: 150 mg qd; CrCl <30: 100 mg qd

HD/PD: not defined

[resistant or tx-intolerant dz, BSA 0.55-0.62 m^2]

CrCl 30-50: 200 mg qd; CrCl <30: 150 mg qd

HD/PD: not defined

[resistant or tx-intolerant dz, BSA 0.63-0.74 m^2]

CrCl <50: 200 mg qd

HD/PD: not defined

[resistant or tx-intolerant dz, BSA 0.75-0.89 m^2]

CrCl 30-50: 250 mg qd; CrCl <30: 200 mg qd

HD/PD: not defined

[resistant or tx-intolerant dz, BSA 0.9-1.09 m^2]

CrCl 30-50: 300 mg qd; CrCl <30: 250 mg qd

HD/PD: not defined

[resistant or tx-intolerant dz, BSA >1.1 m^2]

CrCl 30-50: 400 mg qd; CrCl <30: 300 mg qd

HD/PD: not defined

hepatic dosing

[newly diagnosed dz, BSA <0.9 m^2]

Child-Pugh Class A, B, or C: 100 mg qd

[newly diagnosed dz, BSA 0.9-1.09 m^2]

Child-Pugh Class A, B, or C: 150 mg qd

[newly diagnosed dz, BSA >1.1 m^2]

Child-Pugh Class A, B, or C: 200 mg qd

[resistant or tx-intolerant dz, BSA <0.63 m^2]

Child-Pugh Class A, B, or C: 100 mg qd

[resistant or tx-intolerant dz, BSA 0.63-0.89 m^2]

Child-Pugh Class A, B, or C: 150 mg qd

[resistant or tx-intolerant dz, BSA >0.9 m^2]

Child-Pugh Class A, B, or C: 200 mg qd