Cometriq

Adult Dosing .

Dosage forms:  CAP (60 mg dose pack): 20 mg x84; CAP (100 mg dose pack): 20 mg x28 and 80 mg x28; CAP (140 mg dose pack): 20 mg x84 and 80 mg x28

Special Note

[equivalency or interchangeability info]

Info: not interchangeable with cabozantinib tablets; do not substitute on a mg to mg basis

[uses, dosing may vary]

Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing including toxicity-related dose adjustments; D/C >3wk before elective surgery or invasive dental procedure, restart >2wk after major surgery when wound fully healed

medullary thyroid CA, progressive metastatic

[140 mg PO qd]

Info: give at least 1h before or 2h after meals; do not open cap

renal dosing

[see below]

eGFR >30: no adjustment; eGFR <30: not defined

HD/PD: not defined

hepatic dosing

[see below]

Child-Pugh Class A or B: start 80 mg qd; Child-Pugh Class C: avoid use

Peds Dosing .

Peds dosing is currently unavailable or not applicable for this drug.