Select a medication above to begin.
Pomalyst
pomalidomide
Black Box Warnings .
Appropriate Use
restricted distribution program, PS-Pomalidomide REMS, to minimize fetal exposure; prescribers, pharmacies, and pts must enroll at 1-888-423-5436 or www.PS-PomalidomideREMS.com
Embryo-Fetal Toxicity
contraindicated in pregnancy; females of reproductive potential must have 2 negative pregnancy tests prior to tx start and use 2 reliable contraceptive methods or continuously abstain from heterosexual sex x4wk prior to tx start, during tx and dose interruptions, and x4wk after D/C; pomalidomide is analog of thalidomide, a known human teratogen that causes severe life-threatening birth defects
Venous and Arterial Thromboembolic Events
DVT, PE, MI, and stroke occur in multiple myeloma pts on pomalidomide tx; monitor for thromboembolism s/sx incl. SOB, chest pain, arm or leg swelling, advise pts to seek immediate medical care if they occur; thromboprophylaxis recommended, choice of regimen based on assessment of pt's underlying risk factors
Adult Dosing .
Dosage forms: CAP: 1 mg, 2 mg, 3 mg, 4 mg
Restricted Distribution in US
- [1-888-423-5436 or www.PS-PomalidomideREMS.com for more info]
Special Note
- [uses, dosing may vary]
- Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing incl. toxicity-related dose adjustments
multiple myeloma, relapsed or refractory
- [4 mg PO qd on days 1-21 of 28-day cycle]
- Info: for pts who have received at least 2 prior tx, incl. lenalidomide and a proteasome inhibitor, and w/ dz progression on or w/in 60 days after last tx; use w/ dexamethasone +/- elotuzumab, daratumumab, daratumumab/hyaluronidase, or isatuximab; do not open cap
Kaposi sarcoma
- [5 mg PO qd on days 1-21 of 28-day cycle]
- Info: for pts w/ HIV-negative dz or AIDS-related dz after HAART failure; do not open cap
renal dosing
- [multiple myeloma]
- renal impairment: not defined
- HD: 3 mg qd, on dialysis days admin. after dialysis; no supplement; PD: not defined
- [Kaposi sarcoma]
- renal impairment: not defined
- HD: 4 mg qd, on dialysis days admin. after dialysis; no supplement; PD: not defined
hepatic dosing
- [multiple myeloma]
- Child-Pugh Class A or B: 3 mg qd; Child-Pugh Class C: 2 mg qd
- [Kaposi sarcoma]
- Child-Pugh Class A, B, or C: 3 mg qd
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.