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Signifor
pasireotide
Adult Dosing .
Dosage forms: INJ: 0.3 mg per mL, 0.6 mg per mL, 0.9 mg per mL
Cushing dz
- [0.3-0.9 mg SC bid]
- Start: 0.6 mg or 0.9 mg SC bid; Info: adjust dose in 0.3 mg increments based on tx response and urinary free cortisol levels
renal dosing
- [no adjustment]
- renal impairment: no adjustment
- HD/PD: no adjustment; no supplement
hepatic dosing
- [see below]
- Child-Pugh Class B: start 0.3 mg bid, max 1.2 mg/day; Child-Pugh Class C: avoid use
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.