BAT

Adult Dosing .

Dosage forms:  INJ

Restricted Distribution in US

[distributed directly to CDC]

botulism

[1 vial IV x1]

Start: 0.5 mL/min IV x30min, then may double rate q30min; Max: 2 mL/min; Info: start at lowest rate possible if hypersensitivity risk

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]

Peds Dosing .

Dosage forms:  INJ

Restricted Distribution in US

[distributed directly to CDC]

botulism

[<1 yo]

Dose: 10% of 1 vial IV x1; Start: 0.01 mL/kg/min IV x30 min, then may incr. by 0.01 mL/kg/min q30min; Max: 0.03 mL/kg/min; Info: start at lowest rate possible if hypersensitivity risk; may consider dosing based on toxin load, esp. if large ingestion or exposure

[1-16 yo, 10-14 kg]

Dose: 20% of 1 vial IV x1; Start: 0.01 mL/kg/min IV x30 min, then may incr. by 0.01 mL/kg/min q30min; Max: 0.03 mL/kg/min up to 2 mL/min; Info: start at lowest rate possible if hypersensitivity risk; may consider dosing based on toxin load, esp. if large ingestion or exposure

[1-16 yo, 15-19 kg]

Dose: 30% of 1 vial IV x1; Start: 0.01 mL/kg/min IV x30 min, then may incr. by 0.01 mL/kg/min q30min; Max: 0.03 mL/kg/min up to 2 mL/min; Info: start at lowest rate possible if hypersensitivity risk; may consider dosing based on toxin load, esp. if large ingestion or exposure

[1-16 yo, 20-24 kg]

Dose: 40% of 1 vial IV x1; Start: 0.01 mL/kg/min IV x30 min, then may incr. by 0.01 mL/kg/min q30min; Max: 0.03 mL/kg/min up to 2 mL/min; Info: start at lowest rate possible if hypersensitivity risk; may consider dosing based on toxin load, esp. if large ingestion or exposure

[1-16 yo, 25-29 kg]

Dose: 50% of 1 vial IV x1; Start: 0.01 mL/kg/min IV x30 min, then may incr. by 0.01 mL/kg/min q30min; Max: 0.03 mL/kg/min up to 2 mL/min; Info: start at lowest rate possible if hypersensitivity risk; may consider dosing based on toxin load, esp. if large ingestion or exposure

[1-16 yo, 30-34 kg]

Dose: 60% of 1 vial IV x1; Start: 0.01 mL/kg/min IV x30 min, then may incr. by 0.01 mL/kg/min q30min; Max: 0.03 mL/kg/min up to 2 mL/min; Info: start at lowest rate possible if hypersensitivity risk; may consider dosing based on toxin load, esp. if large ingestion or exposure

[1-16 yo, 35-39 kg]

Dose: 65% of 1 vial IV x1; Start: 0.01 mL/kg/min IV x30 min, then may incr. by 0.01 mL/kg/min q30min; Max: 0.03 mL/kg/min up to 2 mL/min; Info: start at lowest rate possible if hypersensitivity risk; may consider dosing based on toxin load, esp. if large ingestion or exposure

[1-16 yo, 40-44 kg]

Dose: 70% of 1 vial IV x1; Start: 0.01 mL/kg/min IV x30 min, then may incr. by 0.01 mL/kg/min q30min; Max: 0.03 mL/kg/min up to 2 mL/min; Info: start at lowest rate possible if hypersensitivity risk; may consider dosing based on toxin load, esp. if large ingestion or exposure

[1-16 yo, 45-49 kg]

Dose: 75% of 1 vial IV x1; Start: 0.01 mL/kg/min IV x30 min, then may incr. by 0.01 mL/kg/min q30min; Max: 0.03 mL/kg/min up to 2 mL/min; Info: start at lowest rate possible if hypersensitivity risk; may consider dosing based on toxin load, esp. if large ingestion or exposure

[1-16 yo, 50-54 kg]

Dose: 80% of 1 vial IV x1; Start: 0.5 mL/min IV x30 min, then may incr. by 0.01 mL/kg/min q30min; Max: 0.03 mL/kg/min up to 2 mL/min; Info: start at lowest rate possible if hypersensitivity risk; may consider dosing based on toxin load, esp. if large ingestion or exposure

[1-16 yo, >55 kg]

Dose: 1 vial IV x1; Start: 0.5 mL/min IV x30min, then may incr. by 0.01 mL/kg/min q30min; Max: 0.03 mL/kg/min up to 2 mL/min; Info: start at lowest rate possible if hypersensitivity risk

[17 yo and older]

Dose: 1 vial IV x1; Start: 0.5 mL/min IV x30min, then may double rate q30min; Max: 2 mL/min; Info: start at lowest rate possible if hypersensitivity risk

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]