Gazyva

Black Box Warnings .

Adult Dosing .

Dosage forms:  INJ

Special Note

[uses, dosing may vary]

Info: refer to institution protocols and pkg insert prior to prescribing for uses, premeds, and dosing including toxicity-related dose adjustments

CLL/SLL, previously untreated

[1000 mg IV x1 on day 1 of 28-day cycle, starting cycle 2]

Start: 100 mg IV x1 on day 1, then 900 mg IV x1 on day 2, then 1000 mg IV x1 on days 8, 15 of 28-day cycle for cycle 1; Info: give x6 cycles; use with acalabrutinib, chlorambucil, ibrutinib, or venetoclax

follicular lymphoma

[previously untreated disease, combo with bendamustine]

Dose: 1000 mg IV q2mo up to 24mo, starting after 1st 6 cycles complete; Start: 1000 mg IV x1 on days 1, 8, 15 of 28-day cycle for cycle 1, then 1000 mg IV x1 on day 1 of 28-day cycle x5 cycles; Info: use with bendamustine for 1st 6 cycles

[previously untreated disease, combo with CHOP]

Dose: 1000 mg IV q2mo up to 24mo, starting after 1st 8 cycles complete; Start: 1000 mg IV x1 on days 1, 8, 15 of 21-day cycle for cycle 1, then 1000 mg IV x1 on day 1 of 21-day cycle x7 cycles; Info: use with CHOP for 1st 6 cycles

[previously untreated disease, combo with CVP]

Dose: 1000 mg IV q2mo up to 24mo, starting after 1st 8 cycles complete; Start: 1000 mg IV x1 on days 1, 8, 15 of 21-day cycle for cycle 1, then 1000 mg IV x1 on day 1 of 21-day cycle x7 cycles; Info: use with CVP for 1st 8 cycles

[relapsed disease, combo with bendamustine]

Dose: 1000 mg IV q2mo up to 24mo, starting after 1st 6 cycles complete; Start: 1000 mg IV x1 on days 1, 8, 15 of 28-day cycle for cycle 1, then 1000 mg IV x1 on day 1 of 28-day cycle x5 cycles; Info: use with bendamustine for 1st 6 cycles

[relapsed or refractory disease, combo with zanubrutinib (off-label)]

Dose: 1000 mg IV q2mo up to 24mo, starting after 1st 6 cycles complete; Start: 1000 mg IV x1 on days 1, 8, 15 of 28-day cycle for cycle 1, then 1000 mg IV x1 on day 1 of 28-day cycle x5 cycles; Info: for patients refractory to at least 2 prior tx

lupus nephritis

[1000 mg IV q6mo]

Start: 1000 mg IV x1 on wk 0, 2, 24, 26, then q6mo

B-cell depleting pretreatment, pre-glofitamab (off-label)

[1000 mg IV x1]

Start: 7 days prior to glofitamab tx; Info: for patients with relapsed or refractory large B-cell lymphoma

renal dosing

[see below]

renal impairment: no adjustment

HD/PD: not defined

hepatic dosing

[not defined]

Peds Dosing .

Peds dosing is currently unavailable or not applicable for this drug.