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Zorvolex
diclofenac
Black Box Warnings .
Cardiovascular Thrombotic Event
NSAIDs incr. risk of serious and potentially fatal cardiovascular thrombotic events, incl. MI and stroke; risk may occur early in tx and may incr. w/ duration of use; contraindicated in CABG periop setting
GI Bleeding, Ulceration, and Perforation
NSAIDs incr. risk of serious and potentially fatal GI adverse events incl. bleeding, ulcer, and stomach or intestine perforation; GI events may occur at any time during use and w/o warning sx; elderly pts and pts w/ hx of PUD or GI bleeding at greater risk for serious GI events
Adult Dosing .
Dosage forms: CAP: 18 mg, 35 mg
Special Note
- [formulation clarification]
- Info: diclofenac not interchangeable w/ diclofenac potassium or diclofenac sodium products; do not substitute on a mg to mg basis
pain, mild-moderate
- [18-35 mg PO tid]
- Info: use lowest effective dose, shortest effective tx duration; give w/ food if GI upset occurs
osteoarthritis
- [35 mg PO tid]
- Info: use lowest effective dose, shortest effective tx duration; give w/ food if GI upset occurs
renal dosing
- [see below]
- CrCl <30: avoid use; advanced renal dz: avoid use
- HD/PD: avoid use
hepatic dosing
- [adjust dose amount]
- hepatic impairment: max 54 mg/day
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.