Alprolix

Adult Dosing .

Dosage forms:  INJ

hemophilia B

[bleeding episode, minor-moderate]

Dose: individualize dose IV x1; may repeat dose q48h until hemostasis; Info: estimated dose (units) is [wt (kg) x desired factor IX level (%) x 1] where desired factor IX level 30-60%; 1 unit/kg will incr. factor IX level 1%; dose, duration varies by site/severity of bleeding, severity of deficiency, and presence of inhibitors

[bleeding episode, major]

Dose: individualize dose IV x1; may repeat dose after 6-10h, then q24h x3 days, then q48h until hemostasis; Info: estimated dose (units) is [wt (kg) x desired factor IX level (%) x 1] where desired factor IX level 80-100%; 1 unit/kg will incr. factor IX level 1%; dose, duration varies by site/severity of bleeding, severity of deficiency, and presence of inhibitors

[bleeding prophylaxis, minor surgery]

Dose: individualize dose IV x1; may repeat dose q24-48h until hemostasis; Info: estimated dose (units) is [wt (kg) x desired factor IX level (%) x 1] where desired factor IX level 50-80%; 1 unit/kg will incr. factor IX level 1%; dose, duration varies by site/severity of bleeding, severity of deficiency, and presence of inhibitors

[bleeding prophylaxis, major surgery]

Dose: individualize dose IV x1; may repeat dose after 6-10h, then q24h x3 days, then q48h until hemostasis; Info: estimated dose (units) is [wt (kg) x desired factor IX level (%) x 1] where desired factor IX level 60-100%; 1 unit/kg will incr. factor IX level 1%; dose, duration varies by site/severity of bleeding, severity of deficiency, and presence of inhibitors

[routine bleeding prophylaxis]

Dose: individualize dose IV q7-10 days; Start: 50 units/kg/dose IV qwk or 100 units/kg/dose IV q10 days; Info: 1 unit/kg will incr. factor IX level 1%

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]

Peds Dosing .

Dosage forms:  INJ

hemophilia B

[bleeding episode, minor-moderate]

Dose: individualize dose IV x1; may repeat dose q48h until hemostasis; Info: estimated dose (units) is [wt (kg) x desired factor IX level (%) x 1] where desired factor IX level 30-60%; 1 unit/kg will incr. factor IX level 1% if 6 yo and older, 1 unit/kg will incr. factor IX level 0.6% if <6 yo; dose, duration varies by age, site/severity of bleeding, severity of deficiency, and presence of inhibitors

[bleeding episode, major]

Dose: individualize dose IV x1; may repeat dose after 6-10h, then q24h x3 days, then q48h until hemostasis; Info: estimated dose (units) is [wt (kg) x desired factor IX level (%) x 1] where desired factor IX level 80-100%; 1 unit/kg will incr. factor IX level 1% if 6 yo and older, 1 unit/kg will incr. factor IX level 0.6% if <6 yo; dose, duration varies by age, site/severity of bleeding, severity of deficiency, and presence of inhibitors

[bleeding prophylaxis, minor surgery]

Dose: individualize dose IV x1; may repeat dose q24-48h until hemostasis; Info: estimated dose (units) is [wt (kg) x desired factor IX level (%) x 1] where desired factor IX level 50-80%; 1 unit/kg will incr. factor IX level 1% if 6 yo and older, 1 unit/kg will incr. factor IX level 0.6% if <6 yo; dose, duration varies by age, site/severity of bleeding, severity of deficiency, and presence of inhibitors

[bleeding prophylaxis, major surgery]

Dose: individualize dose IV x1; may repeat dose after 6-10h, then q24h x3 days, then q48h until hemostasis; Info: estimated dose (units) is [wt (kg) x desired factor IX level (%) x 1] where desired factor IX level 60-100%; 1 unit/kg will incr. factor IX level 1% if 6 yo and older, 1 unit/kg will incr. factor IX level 0.6% if <6 yo; dose, duration varies by age, site/severity of bleeding, severity of deficiency, and presence of inhibitors

[routine bleeding prophylaxis, <12 yo]

Dose: individualize dose IV qwk; Start: 60 units/kg/dose IV qwk; Info: 1 unit/kg will incr. factor IX level 1% if 6 yo and older, 1 unit/kg will incr. factor IX level 0.6% if <6 yo

[routine bleeding prophylaxis, 12 yo and older]

Dose: individualize dose IV q7-10 days; Start: 50 units/kg/dose IV qwk or 100 units/kg/dose IV q10 days; Info: 1 unit/kg will incr. factor IX level 1%

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]