Select a medication above to begin.
Qudexy XR
topiramate
Adult Dosing .
Dosage forms: ER SPRINKLE CAP: 25 mg, 50 mg, 100 mg, 150 mg, 200 mg
partial seizures
- [monotherapy]
- Dose: 400 mg PO qd; Start: 50 mg PO qd x1wk, then incr. by 50 mg/day qwk until 200 mg PO qd, then incr. by 100 mg/day qwk; Info: may open cap, but do not crush/chew contents; taper dose gradually to D/C
- [adjunct tx]
- Dose: 200-400 mg PO qd; Start: 25-50 mg PO qd x1wk, then incr. by 25-50 mg/day qwk; Info: doses >400 mg/day rarely more effective, may incr. ADR risk; may open cap, but do not crush/chew contents; taper dose gradually to D/C
seizures, primary generalized tonic clonic
- [monotherapy]
- Dose: 400 mg PO qd; Start: 50 mg PO qd x1wk, then incr. by 50 mg/day qwk until 200 mg PO qd, then incr. by 100 mg/day qwk; Info: may open cap, but do not crush/chew contents; taper dose gradually to D/C
- [adjunct tx]
- Dose: 400 mg PO qd; Start: 25-50 mg PO qd x1wk, then incr. by 25-50 mg/day qwk; Info: may open cap, but do not crush/chew contents; taper dose gradually to D/C
seizures, Lennox-Gastaut syndrome
- [adjunct tx]
- Dose: 200-400 mg PO qd; Start: 25-50 mg PO qd x1wk, then incr. by 25-50 mg/day qwk; Info: may open cap, but do not crush/chew contents; taper dose gradually to D/C
migraine prophylaxis
- [100 mg PO qd]
- Start: 25 mg PO qd x1wk, then incr. by 25 mg/day qwk; Max: 200 mg/day; Info: may open cap, but do not crush/chew contents; taper dose gradually to D/C
cyclic vomiting syndrome prophylaxis, moderate-severe (off-label)
- [100 mg PO qd]
- Start: 25 mg PO qd, incr. by 25 mg/day qwk; Info: may open cap, but do not crush/chew contents; taper dose gradually to D/C
renal dosing
- [adjust dose amount]
- CrCl <70: decr. usual dose by 50%
- HD: decr. usual dose, amount not defined, on dialysis days admin. after dialysis; consider supplement if next maint. dose not due right after dialysis; PD: not defined
hepatic dosing
- [see below]
- hepatic impairment: not defined, caution advised
Peds Dosing .
- Dosage forms: ER SPRINKLE CAP: 25 mg, 50 mg, 100 mg, 150 mg, 200 mg
partial seizures, monotherapy
- [2-9 yo, <11 kg]
- Dose: 150-250 mg PO qd; Start: 25 mg PO qhs x1wk, then 50 mg PO qd x1wk, then incr. by 25-50 mg/day qwk; Max: 250 mg/day; Info: may open cap, but do not crush/chew contents; taper dose gradually to D/C
- [2-9 yo, 12-22 kg]
- Dose: 200-300 mg PO qd; Start: 25 mg PO qhs x1wk, then 50 mg PO qd x1wk, then incr. by 25-50 mg/day qwk; Max: 300 mg/day; Info: may open cap, but do not crush/chew contents; taper dose gradually to D/C
- [2-9 yo, 23-31 kg]
- Dose: 200-350 mg PO qd; Start: 25 mg PO qhs x1wk, then 50 mg PO qd x1wk, then incr. by 25-50 mg/day qwk; Max: 350 mg/day; Info: may open cap, but do not crush/chew contents; taper dose gradually to D/C
- [2-9 yo, 32-38 kg]
- Dose: 250-350 mg PO qd; Start: 25 mg PO qhs x1wk, then 50 mg PO qd x1wk, then incr. by 25-50 mg/day qwk; Max: 350 mg/day; Info: may open cap, but do not crush/chew contents; taper dose gradually to D/C
- [2-9 yo, >39 kg]
- Dose: 250-400 mg PO qd; Start: 25 mg PO qhs x1wk, then 50 mg PO qd x1wk, then incr. by 25-50 mg/day qwk; Max: 400 mg/day; Info: may open cap, but do not crush/chew contents; taper dose gradually to D/C
- [10 yo and older]
- Dose: 400 mg PO qd; Start: 50 mg PO qd x1wk, then incr. by 50 mg/day qwk until 200 mg PO qd, then incr. by 100 mg/day qwk; Info: may open cap, but do not crush/chew contents; taper dose gradually to D/C
partial seizures, adjunct tx
- [2-16 yo]
- Dose: 5-9 mg/kg/dose PO qd; Start: 25 mg PO qhs x1wk, then incr. by 1-3 mg/kg/day q1-2wk; Max: 400 mg/day; Info: may open cap, but do not crush/chew contents; taper dose gradually to D/C
primary generalized tonic clonic seizures, monotherapy
- [2-9 yo, <11 kg]
- Dose: 150-250 mg PO qd; Start: 25 mg PO qhs x1wk, then 50 mg PO qd x1wk, then incr. by 25-50 mg/day qwk; Max: 250 mg/day; Info: may open cap, but do not crush/chew contents; taper dose gradually to D/C
- [2-9 yo, 12-22 kg]
- Dose: 200-300 mg PO qd; Start: 25 mg PO qhs x1wk, then 50 mg PO qd x1wk, then incr. by 25-50 mg/day qwk; Max: 300 mg/day; Info: may open cap, but do not crush/chew contents; taper dose gradually to D/C
- [2-9 yo, 23-31 kg]
- Dose: 200-350 mg PO qd; Start: 25 mg PO qhs x1wk, then 50 mg PO qd x1wk, then incr. by 25-50 mg/day qwk; Max: 350 mg/day; Info: may open cap, but do not crush/chew contents; taper dose gradually to D/C
- [2-9 yo, 32-38 kg]
- Dose: 250-350 mg PO qd; Start: 25 mg PO qhs x1wk, then 50 mg PO qd x1wk, then incr. by 25-50 mg/day qwk; Max: 350 mg/day; Info: may open cap, but do not crush/chew contents; taper dose gradually to D/C
- [2-9 yo, >39 kg]
- Dose: 250-400 mg PO qd; Start: 25 mg PO qhs x1wk, then 50 mg PO qd x1wk, then incr. by 25-50 mg/day qwk; Max: 400 mg/day; Info: may open cap, but do not crush/chew contents; taper dose gradually to D/C
- [10 yo and older]
- Dose: 400 mg PO qd; Start: 50 mg PO qd x1wk, then incr. by 50 mg/day qwk until 200 mg PO qd, then incr. by 100 mg/day qwk; Info: may open cap, but do not crush/chew contents; taper dose gradually to D/C
primary generalized tonic clonic seizures, adjunct tx
- [2-16 yo]
- Dose: 5-9 mg/kg/dose PO qd; Start: 25 mg PO qhs x1wk, then incr. by 1-3 mg/kg/day q1-2wk; Max: 400 mg/day; Info: may open cap, but do not crush/chew contents; taper dose gradually to D/C
seizures, Lennox-Gastaut syndrome
- [adjunct tx, 2-16 yo]
- Dose: 5-9 mg/kg/dose PO qd; Start: 25 mg PO qhs x1wk, then incr. by 1-3 mg/kg/day q1-2wk; Max: 400 mg/day; Info: may open cap, but do not crush/chew contents; taper dose gradually to D/C
migraine prophylaxis
- [12 yo and older]
- Dose: 100 mg PO qd; Start: 25 mg PO qd x1wk, then incr. by 25 mg/day qwk; Max: 200 mg/day; Info: may open cap, but do not crush/chew contents; taper dose gradually to D/C
renal dosing
- [adjust dose amount]
- CrCl <70: decr. usual dose by 50%
- HD: decr. usual dose, amount not defined, on dialysis days admin. after dialysis; consider supplement if next maint. dose not due right after dialysis; PD: not defined
hepatic dosing
- [see below]
- hepatic impairment: not defined, caution advised