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Epivir HBV
lamivudine
Black Box Warnings .
HIV testing
offer HIV counseling and testing before initiating lamivudine tx for HBV and periodically during tx; rapid emergence of HIV resistance may occur if unrecognized or untreated HIV infection due to subtherapeutic dose and inappropriate monotherapy with lamivudine tx for HBV
Hepatitis B Exacerbation
severe acute HBV exacerbations upon lamivudine D/C; monitor hepatic function closely for at least several months if D/C tx; initiate anti-HBV tx if needed
Adult Dosing .
Dosage forms: TAB: 100 mg; SOLUTION: 5 mg per mL
hepatitis B infection, chronic
- [100 mg PO qd]
- Info: higher doses required for patients with HIV co-infection
hepatitis B infection prophylaxis, perinatal transmission (off-label)
- [100 mg PO qd]
- Start: at 28-32 wk gestation; Info: for pregnant patients with HBV DNA >200,000; not 1st-line agent; D/C between birth to 3mo postpartum
renal dosing
- [see below]
- CrCl 30-49: 100 mg x1, then 50 mg qd; CrCl 15-29: 100 mg x1, then 25 mg qd; CrCl 5-14: 35 mg x1, then 15 mg qd; CrCl <5: 35 mg x1, then 10 mg qd
- HD: 35 mg x1, then 10-15 mg qd; no supplement; PD: not defined
hepatic dosing
- [no adjustment]
Peds Dosing .
- Dosage forms: TAB: 100 mg; SOLUTION: 5 mg per mL
hepatitis B infection, chronic
- [2 yo and older]
- Dose: 3 mg/kg/dose PO qd; Max: 100 mg/day; Info: higher doses required for patients with HIV co-infection
hepatitis B infection prophylaxis, perinatal transmission (off-label)
- [100 mg PO qd]
- Start: at 28-32 wk gestation; Info: for pregnant patients with HBV DNA >200,000; not 1st-line agent; D/C between birth to 3mo postpartum
renal dosing
- [not defined]
- renal impairment: consider adult renal dosing for guidance
- HD/PD: consider adult renal dosing for guidance
hepatic dosing
- [no adjustment]