Yondelis

Adult Dosing .

Dosage forms:  INJ

Special Note

[uses, dosing may vary]

Info: refer to institution protocols and pkg insert prior to prescribing for uses, premeds, and dosing incl. toxicity-related dose adjustments

liposarcoma, metastatic or unresectable

[1.5 mg/m^2/24h IV infusion q3wk]

leiomyosarcoma, metastatic or unresectable

[1.5 mg/m^2/24h IV infusion q3wk]

renal dosing

[see below]

CrCl >30: no adjustment; CrCl <30: not defined

HD/PD: not defined

hepatic dosing

[see below]

bilirubin 1.6-3x ULN and AST/ALT <8x ULN: 0.9 mg/m^2/dose q3wk; bilirubin >3x ULN: avoid use

Peds Dosing .

Peds dosing is currently unavailable or not applicable for this drug.