Cotellic

Adult Dosing .

Dosage forms:  TAB: 20 mg

Special Note

[uses, dosing may vary]

Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing including toxicity-related dose adjustments

melanoma, unresectable or metastatic

[60 mg PO qd on days 1-21 of 28-day cycle]

Info: for patients with BRAF V600E or V600K mutation; use with vemurafenib with or without atezolizumab

histiocytic neoplasm

[60 mg PO qd on days 1-21 of 28-day cycle]

renal dosing

[see below]

CrCl >30: no adjustment; CrCl <30: not defined

HD/PD: not defined

hepatic dosing

[no adjustment]

Peds Dosing .

Peds dosing is currently unavailable or not applicable for this drug.