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Anthim
obiltoxaximab
Black Box Warnings .
Appropriate Use
must admin. in monitored setting w/ appropriate equipment and trained healthcare professionals to manage anaphylaxis
Hypersensitivity and Anaphylaxis
may occur during tx; monitor pts for hypersensitivity rxn s/sx during infusion and for a period of time after admin; D/C tx immed. and treat appropriately if hypersensitivity rxn or anaphylaxis occurs
Adult Dosing .
Dosage forms: INJ
Restricted Distribution in US
- [distributed directly to CDC]
inhalational anthrax tx
- [>40 kg]
- Dose: 16 mg/kg/dose IV x1; Info: premed w/ diphenhydramine
inhalational anthrax prophylaxis, post-exposure
- [>40 kg]
- Dose: 16 mg/kg/dose IV x1; Info: not 1st-line agent; premed w/ diphenhydramine
renal dosing
- [not defined]
- renal impairment: not defined
- HD/PD: not defined
hepatic dosing
- [not defined]
Peds Dosing .
- Dosage forms: INJ
Restricted Distribution in US
- [distributed directly to CDC]
inhalational anthrax tx
- [<15 kg]
- Dose: 32 mg/kg/dose IV x1; Info: premed w/ diphenhydramine
- [16-40 kg]
- Dose: 24 mg/kg/dose IV x1; Info: premed w/ diphenhydramine
- [>40 kg]
- Dose: 16 mg/kg/dose IV x1; Info: premed w/ diphenhydramine
inhalational anthrax prophylaxis, post-exposure
- [<15 kg]
- Dose: 32 mg/kg/dose IV x1; Info: not 1st-line agent; premed w/ diphenhydramine
- [16-40 kg]
- Dose: 24 mg/kg/dose IV x1; Info: not 1st-line agent; premed w/ diphenhydramine
- [>40 kg]
- Dose: 16 mg/kg/dose IV x1; Info: not 1st-line agent; premed w/ diphenhydramine
renal dosing
- [not defined]
- renal impairment: not defined
- HD/PD: not defined
hepatic dosing
- [not defined]