Kisqali Femara Co-Pack

Adult Dosing .

Dosage forms:  200 mg convenience pack; 400 mg convenience pack; 600 mg convenience pack

Dosage Form Details

[200 mg daily dose convenience pack components]

Info: 28-day pack contains ribociclib 200 mg tab x21 and letrozole 2.5 mg tab x28

[400 mg daily dose convenience pack components]

Info: 28-day pack contains ribociclib 200 mg tab x42 and letrozole 2.5 mg tab x28

[600 mg daily dose convenience pack components]

Info: 28-day pack contains ribociclib 200 mg tab x63 and letrozole 2.5 mg tab x28

Special Note

[uses, dosing may vary]

Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing incl. toxicity-related dose adjustments

hormone receptor-positive HER2-negative breast CA

[high-risk stage II or III early dz, adjuvant tx]

Dose: ribociclib 400 mg PO qam + letrozole 2.5 mg PO qam on days 1-21 of 28-day cycle, then letrozole 2.5 mg PO qam on days 22-28 of 28-day cycle x3y; Info: give w/ LHRH agonist in pre/perimenopausal patients or male patients; do not cut/crush/chew tab

[advanced or metastatic dz, initial tx]

Dose: ribociclib 600 mg PO qam + letrozole 2.5 mg PO qam on days 1-21 of 28-day cycle, then letrozole 2.5 mg PO qam on days 22-28 of 28-day cycle; Info: give w/ LHRH agonist in pre/perimenopausal patients or male patients; do not cut/crush/chew tab

renal dosing

[ribociclib component]

severe impairment: start 200 mg qam

HD/PD: not defined

[letrozole component]

CrCl >10: no adjustment; CrCl <10: not defined

HD/PD: not defined

hepatic dosing

[ribociclib component, early dz]

hepatic impairment: no adjustment

[ribociclib component, advanced or metastatic dz]

Child-Pugh Class B or C: start 400 mg qam

[letrozole component]

cirrhosis/Child-Pugh Class C: give usual dose q48h

Peds Dosing .

Peds dosing is currently unavailable or not applicable for this drug.