Rituxan Hycela

Adult Dosing .

Dosage forms:  INJ: 120 mg/2000 units per mL

Special Note

[strength clarification]

Info: doses expressed as rituximab amt; 1400 mg of combo contains 1400 mg rituximab + 23,400 units hyaluronidase; 1600 mg of combo contains 1600 mg rituximab + 26,800 units hyaluronidase

[uses, dosing may vary]

Info: refer to institution protocols and pkg insert prior to prescribing for uses, premeds, and dosing incl. toxicity-related dose adjustments

non-Hodgkin lymphoma, follicular

[relapsed or refractory dz]

Dose: 1400 mg SC qwk x3wk or x7wk, starting wk 2; Info: start after tolerating IV rituximab x1 at wk 1; give total 4 or 8wk of rituximab; may give additional 4wk tx (IV rituximab at wk 1, then SC rituximab qwk x3wk) in pts who progress after initial tx; give HBV prophylaxis before tx start, during tx, and for up to 12mo after D/C in anti-HBc positive pts

[previously untreated dz]

Dose: 1400 mg SC x1 on day 1 of 21-day cycle, starting cycle 2; Info: start after tolerating IV rituximab x1 on day 1 of cycle 1; give up to 8 cycles of rituximab as part of multi-drug chemo regimen; if complete or partial response, may give maint. monotherapy 1400 mg SC x1 on day 1 of 56-day cycle x12 cycles starting 56 days after combo chemo; give HBV prophylaxis before tx start, during tx, and for up to 12mo after D/C in anti-HBc positive pts

[non-progressing dz]

Dose: 1400 mg SC x1 on days 1, 8, 15, 22 of 6-mo cycle, starting cycle 2; Start: 1400 mg SC x1 on days 8, 15, 22 of cycle 1; Info: start after tolerating IV rituximab x1 on day 1 of cycle 1; give up to 16 doses (4 cycles) of rituximab; give HBV prophylaxis before tx start, during tx, and for up to 12mo after D/C in anti-HBc positive pts

non-Hodgkin lymphoma, diffuse large B-cell

[1400 mg SC x1 on day 1 of each cycle, starting cycle 2]

Info: for previously untreated dz; start after tolerating IV rituximab x1 on day 1 of cycle 1; give up to 8 cycles of rituximab; part of multi-drug chemo regimen; give HBV prophylaxis before tx start, during tx, and for up to 12mo after D/C in anti-HBc positive pts

CLL/SLL

[1600 mg SC x1 on day 1 of 28-day cycle, starting cycle 2]

Info: start after tolerating IV rituximab x1 on day 1 of cycle 1; give total 6 cycles of rituximab; part of multi-drug chemo regimen; give HSV and PCP prophylaxis during tx and up to 12mo after D/C; give HBV prophylaxis before tx start, during tx, and for up to 12mo after D/C in anti-HBc positive pts

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]

Peds Dosing .

Peds dosing is currently unavailable or not applicable for this drug.