metyrosine

Adult Dosing .

Dosage forms:  CAP: 250 mg

pheochromocytoma

[2-3 g/day PO in divided doses]

Start: 250 mg PO qid, may incr. by 250-500 mg/day; Max: 4 g/day in divided doses; Info: maintain urine output >2 L/day; titrate dose based on BP, catecholamine excretion; may consider adding alpha-adrenergic blocker if inadequate response; for preop use, achieve effective dose >5-7 days before surgery

renal dosing

[see below]

renal impairment: not defined, caution advised

HD/PD: not defined

hepatic dosing

[see below]

hepatic impairment: not defined, caution advised

Peds Dosing .

Dosage forms:  CAP: 250 mg

pheochromocytoma

[12 yo and older]

Dose: 2-3 g/day PO in divided doses; Start: 250 mg PO qid, may incr. by 250-500 mg/day; Max: 4 g/day in divided doses; Info: maintain urine output >2 L/day; titrate dose based on BP, catecholamine excretion; may consider adding alpha-adrenergic blocker if inadequate response; for preop use, achieve effective dose >5-7 days before surgery

renal dosing

[see below]

renal impairment: not defined, caution advised

HD/PD: not defined

hepatic dosing

[see below]

hepatic impairment: not defined, caution advised