Metopirone

Adult Dosing .

Dosage forms:  CAP: 250 mg

Restricted Distribution in US

[1-844-597-6373 or www.metopirone.com for more info]

adrenal insufficiency, diagnosis

[30 mg/kg/dose PO x1]

Start: after adequate response to standard ACTH test; Max: 3 g/dose; Info: give at midnight w/ yogurt, milk, or snack; check plasma ACTH and 11-desoxycortisol 8h after dose; consider giving corticosteroid after levels drawn if high risk for acute adrenal insufficiency

Cushing syndrome (off-label)

[0.5-6 g/day PO divided tid-qid]

Start: 0.5-1 g/day PO divided tid-qid; Max: 6 g/day; Info: adjust dose based on clinical response and urinary free cortisol levels or serum cortisol levels

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]

Peds Dosing .

Dosage forms:  CAP: 250 mg

Restricted Distribution in US

[1-844-597-6373 or www.metopirone.com for more info]

adrenal insufficiency, diagnosis

[30 mg/kg/dose PO x1]

Start: after adequate response to standard ACTH test; Max: 3 g/dose; Info: give at midnight w/ yogurt, milk, or snack; check plasma ACTH and 11-desoxycortisol 8h after dose; consider giving corticosteroid after levels drawn if high risk for acute adrenal insufficiency

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]