Prevymis

Adult Dosing .

Dosage forms:  TAB: 240 mg, 480 mg; PELLET: 20 mg per pkt, 120 mg per pkt; INJ: various

CMV prophylaxis, allogeneic HSCT

[480 mg PO/IV qd until 100 days post-transplant]

Start: between days 0 and 28 of transplant; Info: for CMV seropositive recipients; may continue until 200 days post-transplant in pts w/ late CMV infection and dz risk; switch to PO form when possible; do not chew/crush pellet

CMV prophylaxis, kidney transplant

[480 mg PO/IV qd until 200 days post-transplant]

Start: between days 0 and 7 of transplant; Info: for donor CMV seropositive/recipient CMV seronegative pts; switch to PO form when possible; do not chew/crush pellet

renal dosing

[PO route]

CrCl >10: no adjustment; CrCl <10: not defined

HD/PD: not defined

[IV route]

CrCl >50: no adjustment; CrCl <50: not defined, caution advised; Info: risk of IV vehicle accumulation

HD/PD: not defined

hepatic dosing

[see below]

Child-Pugh Class C: avoid use

Peds Dosing .

Dosage forms:  TAB: 240 mg, 480 mg; PELLET: 20 mg per pkt, 120 mg per pkt; INJ: various

CMV prophylaxis, allogeneic HSCT

[6 mo and older, 6-7.4 kg]

Dose: 40 mg IV qd until 100 days post-transplant; Start: between days 0 and 28 of transplant; Alt: 80 mg PO qd until 100 days post-transplant; Info: for CMV seropositive recipients; may continue until 200 days post-transplant in pts w/ late CMV infection and dz risk; do not chew/crush pellet

[6 mo and older, 7.5-14 kg]

Dose: 60 mg IV qd until 100 days post-transplant; Start: between days 0 and 28 of transplant; Alt: 120 mg PO qd until 100 days post-transplant; Info: for CMV seropositive recipients; may continue until 200 days post-transplant in pts w/ late CMV infection and dz risk; do not chew/crush pellet

[6 mo and older, 15-29 kg]

Dose: 120 mg IV qd until 100 days post-transplant; Start: between days 0 and 28 of transplant; Alt: 240 mg PO qd until 100 days post-transplant; Info: for CMV seropositive recipients; may continue until 200 days post-transplant in pts w/ late CMV infection and dz risk; switch to PO form when possible; do not chew/crush pellet

[6 mo and older, >30 kg]

Dose: 480 mg PO/IV qd until 100 days post-transplant; Start: between days 0 and 28 of transplant; Info: for CMV seropositive recipients; may continue until 200 days post-transplant in pts w/ late CMV infection and dz risk; switch to PO form when possible; do not chew/crush pellet

CMV prophylaxis, kidney transplant

[12 yo and older, >40 kg]

Dose: 480 mg PO/IV qd until 200 days post-transplant; Start: between days 0 and 7 of transplant; Info: for donor CMV seropositive/recipient CMV seronegative pts; switch to PO form when possible; do not chew/crush pellet

renal dosing

[PO route]

CrCl >10: no adjustment; CrCl <10: not defined

HD/PD: not defined

[IV route]

CrCl >50: no adjustment; CrCl <50: not defined, caution advised; Info: risk of IV vehicle accumulation

HD/PD: not defined

hepatic dosing

[see below]

Child-Pugh Class C: avoid use