Cinvanti

Adult Dosing .

Dosage forms:  INJ

Special Note

[dosing clarification]

Info: for PO aprepitant dosing see aprepitant or Emend; for other IV aprepitant dosing see Aponvie and for IV fosaprepitant dosing see Emend Injection, Focinvez, or fosaprepitant

nausea/vomiting prevention, chemo-related

[highly-emetogenic parenteral chemo]

Dose: 130 mg IV x1 on day 1; Start: 30min before chemo; Info: part of multi-drug regimen; search 'CINV' for epocrates Chemo-Induced Nausea & Vomiting in Adults decision tool

[moderately-emetogenic parenteral chemo, 1-day regimen]

Dose: 130 mg IV x1 on day 1; Start: 30min before chemo; Info: part of multi-drug regimen; search 'CINV' for epocrates Chemo-Induced Nausea & Vomiting in Adults decision tool

[moderately-emetogenic chemo, 3-day regimen]

Dose: 100 mg IV x1 on day 1, then oral aprepitant 80 mg PO qd on days 2-3; Start: 30min before chemo; Info: give w/ corticosteroid and 5-HT3 antagonist

renal dosing

[see below]

renal impairment: no adjustment

HD: no adjustment; no supplement; PD: not defined

hepatic dosing

[see below]

Child-Pugh Class A or B: no adjustment; Child-Pugh Class C: not defined

Peds Dosing .

Dosage forms:  --

Special Note

[dosing clarification]

Info: peds dosing is currently unavailable for this drug; for PO aprepitant dosing see aprepitant or Emend; for IV fosaprepitant dosing see Emend Injection, Focinvez, or fosaprepitant