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Abilify MyCite
aripiprazole
Black Box Warnings .
Dementia-Related Psychosis
not approved for dementia-related psychosis; incr. mortality risk in elderly pts on antipsychotic tx for dementia-related psychosis; most deaths due to cardiovascular or infectious events
Suicidality
incr. suicidality risk in peds and young adult pts in short-term studies; observe all antidepressant-treated pts for clinical worsening, suicidality, or unusual behavior changes; advise families and caregivers of need for close observation and communication w/ prescriber; safety and efficacy not established in peds pts
Adult Dosing .
Dosage forms: starter convenience pack; maintenance convenience pack
Restricted Distribution in US
- [1-844-692-4833 or www.abilifymycite.com for more info]
Special Note
- [formulation clarification]
- Info: tab sensor sends signal to wearable 2-component patch to record drug intake; compatible smartphone app required
- [starter convenience pack components]
- Info: 30-day starter pack contains aripiprazole tab w/ sensor x30 (available tab strengths = 2 mg, 5 mg, 10 mg, 15 mg, 20 mg, or 30 mg) and strip x7 and pod x1
- [maintenance convenience pack components]
- Info: maintenance pack contains aripiprazole tab w/ sensor x30 (available tab strengths = 2 mg, 5 mg, 10 mg, 15 mg, 20 mg, or 30 mg) and strip x7
schizophrenia
- [10-15 mg PO qd]
- Start: 10-15 mg PO qd; may incr. dose q2wk; Max: 30 mg/day; Info: doses >15 mg/day rarely more effective; decr. dose 50% in CYP2D6 poor metabolizers; periodically reassess need for tx; D/C if ANC <1000; consider D/C if unexplained decr. in WBC; do not cut/crush/chew tab
bipolar I disorder, manic/mixed
- [monotherapy]
- Dose: 15 mg PO qd; Max: 30 mg/day; Info: for acute and maintenance tx; decr. dose 50% in CYP2D6 poor metabolizers; periodically reassess need for tx; D/C if ANC <1000; consider D/C if unexplained decr. in WBC; do not cut/crush/chew tab
- [valproate or lithium adjunct]
- Dose: 15 mg PO qd; Start: 10-15 mg PO qd; Max: 30 mg/day; Info: for acute and maintenance tx; decr. dose 50% in CYP2D6 poor metabolizers; periodically reassess need for tx; D/C if ANC <1000; consider D/C if unexplained decr. in WBC; do not cut/crush/chew tab
major depressive disorder, adjunct tx
- [2-15 mg PO qd]
- Start: 2-5 mg PO qd, may incr. by up to 5 mg/day qwk; Max: 15 mg/day; Info: periodically reassess need for tx; D/C if ANC <1000; consider D/C if unexplained decr. in WBC; do not cut/crush/chew tab
renal dosing
- [see below]
- CrCl >15: no adjustment; CrCl <15: not defined
- HD/PD: not defined
hepatic dosing
- [no adjustment]
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.