Yonsa

Adult Dosing .

Dosage forms:  TAB: 125 mg

Special Note

[formulation clarification]

Info: not interchangeable w/ other abiraterone acetate products; do not substitute on a mg to mg basis

[uses, dosing may vary]

Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing incl. toxicity-related dose adjustments

prostate CA

[metastatic castration-resistant dz]

Dose: 500 mg PO qd; Info: use w/ methylprednisolone 4 mg PO bid; use w/ GnRH analog in pts w/o bilateral orchiectomy; do not cut/crush/chew tab

[metastatic castration-sensitive, high-risk dz (off-label)]

Dose: 500 mg PO qd; Info: use w/ methylprednisolone 4 mg PO bid; use w/ GnRH analog in pts w/o bilateral orchiectomy; do not cut/crush/chew tab

[metastatic castration-sensitive, high-volume dz (off-label)]

Dose: 500 mg PO qd; Info: for pts w/ de novo metastatic dz w/ at least 4 bone metastases or any visceral dz; use w/ methylprednisolone 4 mg PO bid and docetaxel; use w/ GnRH analog in pts w/o bilateral orchiectomy; do not cut/crush/chew tab

renal dosing

[see below]

renal impairment: no adjustment

HD: no adjustment; no supplement; PD: not defined

hepatic dosing

[see below]

Child-Pugh Class B: 125 mg qd; Child-Pugh Class C: avoid use

Peds Dosing .

Peds dosing is currently unavailable or not applicable for this drug.