Onpattro

Adult Dosing .

Dosage forms:  INJ

transthyretin amyloid polyneuropathy

[<100 kg]

Dose: 0.3 mg/kg/dose IV q3wk; Info: for patients with hereditary disease; use actual body wt to calculate dose; premed with corticosteroid, acetaminophen, diphenhydramine, and H2 blocker >60min before each infusion; see pkg insert for missed dose recommendations; vitamin A supplementation recommended

[>100 kg]

Dose: 30 mg IV q3wk; Info: for patients with hereditary disease; premed with corticosteroid, acetaminophen, diphenhydramine, and H2 blocker >60min before each infusion; see pkg insert for missed dose recommendations; vitamin A supplementation recommended

renal dosing

[see below]

mild-moderate impairment: no adjustment; severe impairment: not defined

HD/PD: not defined

hepatic dosing

[see below]

mild impairment: no adjustment; moderate-severe impairment: not defined

Peds Dosing .

Peds dosing is currently unavailable or not applicable for this drug.