Select a medication above to begin.
sodium thiosulfate
generic
Adult Dosing .
Dosage forms: INJ
cyanide poisoning, acute life-threatening
- [12.5 g IV x1]
- Info: give immediately after sodium nitrite; if s/sx recur, may repeat x1 at 50% dose for both drugs
extravasation tx, bendamustine-assoc. (off-label)
- [2 mL 1/6 molar (4%) solution for each mg of extravasated bendamustine SC x1]
- Info: use 25-gauge or smaller needle
extravasation tx, cisplatin-assoc. (off-label)
- [IV route]
- Dose: 2 mL 1/6 molar (4%) solution for each 100 mg of extravasated cisplatin IV x1 into existing cannula
- [SC route]
- Dose: 1 mL 1/6 molar (4%) solution SC x1; Info: give as 10 clockwise injections (0.1mL each) into extravasated area; use 25-gauge or smaller needle; change needle w/ each injection; may repeat 1 mL injection several times over 3-4h
extravasation tx, dacarbazine-assoc. (off-label)
- [5 mL 1/6 molar (4%) solution SC x1]
- Info: give as 10 clockwise injections (0.1 mL each) into extravasated area; use 25-gauge or smaller needle; change needle w/ each injection
renal dosing
- [see below]
- renal impairment: not defined, caution advised
- HD/PD: not defined
hepatic dosing
- [not defined]
Peds Dosing .
- Dosage forms: INJ
cyanide poisoning, acute life-threatening
- [250 mg/kg/dose IV x1]
- Max: 12.5 g/dose; Alt: 7.5-10 g/m^2/dose IV x1; Info: give immediately after sodium nitrite; if s/sx recur, may repeat x1 at 50% dose for both drugs
extravasation tx, bendamustine-assoc. (off-label)
- [2 mL 1/6 molar (4%) solution for each mg of extravasated bendamustine SC x1]
- Info: use 25-gauge or smaller needle
extravasation tx, cisplatin-assoc. (off-label)
- [IV route]
- Dose: 2 mL 1/6 molar (4%) solution for each 100 mg of extravasated cisplatin IV x1 into existing cannula
- [SC route]
- Dose: 1 mL 1/6 molar (4%) solution SC x1; Info: give as 10 clockwise injections (0.1mL each) into extravasated area; use 25-gauge or smaller needle; change needle w/ each injection; may repeat 1 mL injection several times over 3-4h
extravasation tx, dacarbazine-assoc. (off-label)
- [5 mL 1/6 molar (4%) solution SC x1]
- Info: give as 10 clockwise injections (0.1 mL each) into extravasated area; use 25-gauge or smaller needle; change needle w/ each injection
renal dosing
- [see below]
- renal impairment: not defined, caution advised
- HD/PD: not defined
hepatic dosing
- [not defined]