Tolsura

itraconazole

Drug Monograph

Black Box Warnings
Adult Dosing
Peds Dosing
Contraindications/Cautions
Drug Interactions
Adverse Reactions
Safety/Monitoring
Pregnancy/Lactation
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Black Box Warnings .

CHF

can cause or exacerbate CHF; negative inotropic effects; D/C if CHF signs/symptoms occur

Drug Interactions

coadministration is contraindicated with methadone, disopyramide, dofetilide, dronedarone, quinidine, isavuconazole, dihydroergotamine, ergotamine, methylergonovine, irinotecan, lurasidone, oral midazolam, pimozide, triazolam, felodipine, nisoldipine, ivabradine, ranolazine, eplerenone, naloxegol, lomitapide, lovastatin, simvastatin, avanafil, ticagrelor, and, in subjects with varying degrees of renal or hepatic impairment, colchicine, fesoterodine, solifenacin; eliglustat coadministration contraindicated in CYP2D6 poor or intermediate metabolizers and in patients taking strong or moderate CYP2D6 inhibitors; elevated plasma concentrations of these drugs may occur, leading to increased or prolonged pharmacologic effects and/or adverse reactions including for some drugs QT prolongation and ventricular tachyarrhythmias including torsades de pointes, a potentially fatal arrhythmia

Adult Dosing .

Dosage forms: CAP: 65 mg

Special Note

[equivalency or interchangeability info]: Info: not interchangeable with other itraconazole products; do not substitute on a mg to mg basis

infections, fungal

[130 mg PO qd-bid]: Start: 130 mg PO tid x3 days for life-threatening infections; Info: dose, duration vary by indication; divide dose bid if >130 mg/day; give with food; do not open cap

blastomycosis

[130 mg PO qd]: Info: may incr. by 65 mg if no improvement, max 260 mg/day; divide dose bid if >130 mg/day; give with food; do not open cap; start 130 mg PO tid x3 days if life-threatening infection

histoplasmosis

[130 mg PO qd]: Info: may incr. by 65 mg if no improvement, max 260 mg/day; divide dose bid if >130 mg/day; give with food; do not open cap; start 130 mg PO tid x3 days if life-threatening infection

aspergillosis

[130 mg PO qd-bid]: Info: divide dose bid if >130 mg/day; give with food; do not open cap; start 130 mg PO tid x3 days if life-threatening infection

renal dosing

[see below]: renal impairment: not defined, caution advised

HD/PD: not defined

hepatic dosing

[see below]: hepatic impairment: not defined, caution advised

Peds Dosing .

Peds dosing is currently unavailable or not applicable for this drug.

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