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Tolsura
itraconazole
Black Box Warnings .
CHF
can cause or exacerbate CHF; negative inotropic effects; D/C if CHF s/sx occur
Drug Interactions
coadministration is contraindicated w/ methadone, disopyramide, dofetilide, dronedarone, quinidine, isavuconazole, dihydroergotamine, ergotamine, methylergonovine, irinotecan, lurasidone, oral midazolam, pimozide, triazolam, felodipine, nisoldipine, ivabradine, ranolazine, eplerenone, naloxegol, lomitapide, lovastatin, simvastatin, avanafil, ticagrelor, and, in subjects w/ varying degrees of renal or hepatic impairment, colchicine, fesoterodine, solifenacin; eliglustat coadministration contraindicated in CYP2D6 poor or intermediate metabolizers and in pts taking strong or moderate CYP2D6 inhibitors; elevated plasma concentrations of these drugs may occur, leading to increased or prolonged pharmacologic effects and/or adverse rxns incl. for some drugs QT prolongation and ventricular tachyarrhythmias incl. torsades de pointes, a potentially fatal arrhythmia
Adult Dosing .
Dosage forms: CAP: 65 mg
Special Note
- [formulation clarification]
- Info: not interchangeable w/ other itraconazole products; do not substitute on a mg to mg basis
infections, fungal
- [130 mg PO qd-bid]
- Start: 130 mg PO tid x3 days for life-threatening infections; Info: dose, duration vary by indication; divide dose bid if >130 mg/day; give w/ food; do not open cap
blastomycosis
- [130 mg PO qd]
- Info: may incr. by 65 mg if no improvement, max 260 mg/day; divide dose bid if >130 mg/day; give w/ food; do not open cap; start 130 mg PO tid x3 days if life-threatening infection
histoplasmosis
- [130 mg PO qd]
- Info: may incr. by 65 mg if no improvement, max 260 mg/day; divide dose bid if >130 mg/day; give w/ food; do not open cap; start 130 mg PO tid x3 days if life-threatening infection
aspergillosis
- [130 mg PO qd-bid]
- Info: divide dose bid if >130 mg/day; give w/ food; do not open cap; start 130 mg PO tid x3 days if life-threatening infection
renal dosing
- [see below]
- renal impairment: not defined, caution advised
- HD/PD: not defined
hepatic dosing
- [see below]
- hepatic impairment: not defined, caution advised
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.