Select a medication above to begin.
Zolgensma (onasemnogene abeparvovec-xioi)
onasemnogene abeparvovec
Black Box Warnings .
Acute Serious Liver Injury and Failure
fatal cases of acute liver failure reported; acute serious liver injury and elevated ALT/AST may occur; pts w/ pre-existing liver impairment may be at higher risk; assess LFTs at baseline, then cont. monitoring for at least 3mo after infusion and as clinically indicated; admin. systemic corticosteroid to all pts before and after infusion
Adult Dosing .
Adult dosing is currently unavailable or not applicable for this drug.
Peds Dosing .
- Dosage forms: INJ
Special Note
- [formulation clarification]
- Info: nonproprietary name = onasemnogene abeparvovec-xioi
spinal muscular atrophy
- [<2 yo]
- Dose: 1.1 x10^14 vector genomes/kg/dose IV x1; Info: for pts w/ biallelic mutations in SMN1 gene; give oral prednisolone 1 mg/kg/day or equivalent for at least 30 days starting 1 day before infusion; taper corticosteroid dose gradually over 28 days to D/C
renal dosing
- [not defined]
- renal impairment: not defined
- HD/PD: not defined
hepatic dosing
- [see below]
- hepatic impairment: not defined, caution advised