Polivy (polatuzumab vedotin-piiq)

Adult Dosing .

Dosage forms:  INJ

Special Note

[drug name clarification]

Info: nonproprietary name = polatuzumab vedotin-piiq

[uses, dosing may vary]

Info: refer to institution protocols and pkg insert prior to prescribing for uses, premeds, and dosing incl. toxicity-related dose adjustments

high grade B-cell lymphoma, previously untreated

[1.8 mg/kg/dose IV x1 on day 1 of 21-day cycle x6 cycles]

Info: for patients w/ International Prognostic Index score 2 or greater; give HSV, PCP prophylaxis during tx; part of multi-drug chemo regimen

diffuse large B-cell lymphoma

[previously untreated dz]

Dose: 1.8 mg/kg/dose IV x1 on day 1 of 21-day cycle x6 cycles; Info: for patients w/ DLBCL, not otherwise specified and International Prognostic Index score 2 or greater; give HSV, PCP prophylaxis during tx; part of multi-drug chemo regimen

[relapsed or refractory dz]

Dose: 1.8 mg/kg/dose IV x1 on day 1 of 21-day cycle x6 cycles; Info: for patients w/ DLBCL, not otherwise specified; give HSV, PCP prophylaxis during tx; part of multi-drug chemo regimen

renal dosing

[see below]

CrCl >30: no adjustment; CrCl <30: not defined

HD/PD: not defined

hepatic dosing

[see below]

bilirubin >1.5x ULN: avoid use

Peds Dosing .

Peds dosing is currently unavailable or not applicable for this drug.