Xpovio

Adult Dosing .

Dosage forms:  TAB (40 mg once weekly pack): 10 mg x16; TAB (40 mg once weekly pack): 40 mg x4; TAB (60 mg once weekly pack): 60 mg x4; TAB (80 mg once weekly pack): 40 mg x8; TAB (100 mg once weekly pack): 50 mg x8; TAB (40 mg twice weekly pack): 40 mg x8; TAB (60 mg twice weekly pack): 20 mg x24; TAB (80 mg twice weekly pack): 20 mg x32

Special Note

[uses, dosing may vary]

Info: refer to institution protocols and pkg insert prior to prescribing for uses, premeds, concomitant meds to mitigate toxicity, and dosing incl. toxicity-related dose adjustments

multiple myeloma, relapsed or refractory

[combo w/ bortezomib and dexamethasone]

Dose: 100 mg PO x1 on day 1 of 7-day cycle; Info: for patients who have received at least 1 prior tx; do not cut/crush/chew tab

[combo w/ dexamethasone]

Dose: 80 mg PO x1 on days 1, 3 of 7-day cycle; Info: for patients who have received at least 4 prior tx, incl. at least 2 proteasome inhibitors, at least 2 immunomodulatory agents, and an anti-CD38 agent; do not cut/crush/chew tab

diffuse large B-cell lymphoma, relapsed or refractory

[60 mg PO x1 on days 1, 3 of 7-day cycle]

Info: for patients who have received at least 2 lines of tx; do not cut/crush/chew tab

renal dosing

[see below]

CrCl >15: no adjustment; CrCl <15: not defined

HD/PD: not defined

hepatic dosing

[see below]

mild impairment: no adjustment; moderate-severe impairment: not defined

Peds Dosing .

Peds dosing is currently unavailable or not applicable for this drug.