Rozlytrek

Adult Dosing .

Dosage forms:  CAP: 100 mg, 200 mg; PELLET: 50 mg per pkt

Special Note

[uses, dosing may vary]

Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing incl. toxicity-related dose adjustments

ROS1-positive non-small cell lung CA, metastatic

[600 mg PO qd]

Info: do not crush/chew cap or pellet; see pkg insert for suspension preparation from cap

neurotrophic receptor tyrosine kinase (NTRK) gene fusion-positive solid tumors, metastatic or unresectable

[600 mg PO qd]

Info: for pts w/ progressive dz; do not crush/chew cap or pellet; see pkg insert for suspension preparation from cap

renal dosing

[see below]

CrCl >30: no adjustment; CrCl <30: not defined

HD/PD: not defined

hepatic dosing

[see below]

bilirubin 1.1-1.5x ULN or AST >ULN: no adjustment; bilirubin >1.5x ULN: not defined

Peds Dosing .

Dosage forms:  CAP: 100 mg, 200 mg; PELLET: 50 mg per pkt

Special Note

[uses, dosing may vary]

Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing incl. toxicity-related dose adjustments

neurotrophic receptor tyrosine kinase (NTRK) gene fusion-positive solid tumors, metastatic or unresectable

[1-6 mo]

Dose: 250 mg/m^2/dose PO qd; Info: for pts w/ progressive dz; do not crush/chew cap or pellet; see pkg insert for suspension preparation from cap

[>6 mo, BSA <0.5 m^2]

Dose: 300 mg/m^2/dose PO qd; Info: for pts w/ progressive dz; do not crush/chew cap or pellet; see pkg insert for suspension preparation from cap

[>6 mo, BSA 0.51-0.8 m^2]

Dose: 200 mg PO qd; Info: for pts w/ progressive dz; do not crush/chew cap or pellet; see pkg insert for suspension preparation from cap

[>6 mo, BSA 0.81-1.1 m^2]

Dose: 300 mg PO qd; Info: for pts w/ progressive dz; do not crush/chew cap or pellet; see pkg insert for suspension preparation from cap

[>6 mo, BSA 1.11-1.5 m^2]

Dose: 400 mg PO qd; Info: for pts w/ progressive dz; do not crush/chew cap or pellet; see pkg insert for suspension preparation from cap

[>6 mo, BSA >1.51 m^2]

Dose: 600 mg PO qd; Info: for pts w/ progressive dz; do not crush/chew cap or pellet; see pkg insert for suspension preparation from cap

renal dosing

[see below]

CrCl >30: no adjustment; CrCl <30: not defined

HD/PD: not defined

hepatic dosing

[see below]

bilirubin 1.1-1.5x ULN or AST >ULN: no adjustment; bilirubin >1.5x ULN: not defined