Tpoxx

Adult Dosing .

Dosage forms:  CAP: 200 mg; INJ: various

Restricted Distribution in US

[distributed directly to CDC and US Dept. of Defense]

smallpox

[PO route, 40-119 kg]

Dose: 600 mg PO bid x14 days; Info: give w/in 30min after full moderate-high fat meal

[PO route, >120 kg]

Dose: 600 mg PO tid x14 days; Info: give w/in 30min after full moderate-high fat meal

[IV route, 35-119 kg]

Dose: 200 mg IV q12h for up to 14 days; Info: switch to PO regimen ASAP to complete course

[IV route, >120 kg]

Dose: 300 mg IV q12h for up to 14 days; Info: switch to PO regimen ASAP to complete course

mpox

[PO route, 40-119 kg]

Dose: 600 mg PO bid x14 days; Info: for pts w/ severe dz or aberrant infection, or at high risk for severe dz; consider giving w/ cidofovir or brincidofovir; may extend duration based on clinical response; give w/in 30min after full moderate-high fat meal

[PO route, >120 kg]

Dose: 600 mg PO tid x14 days; Info: for pts w/ severe dz or aberrant infection, or at high risk for severe dz; consider giving w/ cidofovir or brincidofovir; may extend duration based on clinical response; give w/in 30min after full moderate-high fat meal

[IV route, 35-119 kg]

Dose: 200 mg IV q12h x14 days; Info: for pts w/ severe dz or aberrant infection, or at high risk for severe dz; consider giving w/ cidofovir or brincidofovir; switch to PO regimen ASAP to complete course; may extend duration based on clinical response

[IV route, >120 kg]

Dose: 300 mg IV q12h x14 days; Info: for pts w/ severe dz or aberrant infection, or at high risk for severe dz; consider giving w/ cidofovir or brincidofovir; switch to PO regimen ASAP to complete course; may extend duration based on clinical response

renal dosing

[PO route]

renal impairment: no adjustment

HD/PD: no adjustment; no supplement

[IV route]

CrCl <30: contraindicated; Info: risk of IV vehicle accumulation

HD/PD: contraindicated

hepatic dosing

[no adjustment]

Peds Dosing .

Dosage forms:  CAP: 200 mg; INJ: various

Restricted Distribution in US

[distributed directly to CDC and US Dept. of Defense]

smallpox

[PO route, 13-24 kg]

Dose: 200 mg PO bid x14 days; Info: give w/in 30min after full moderate-high fat meal

[PO route, 25-39 kg]

Dose: 400 mg PO bid x14 days; Info: give w/in 30min after full moderate-high fat meal

[PO route, 40-119 kg]

Dose: 600 mg PO bid x14 days; Info: give w/in 30min after full moderate-high fat meal

[PO route, >120 kg]

Dose: 600 mg PO tid x14 days; Info: give w/in 30min after full moderate-high fat meal

[IV route, 3-34 kg]

Dose: 6 mg/kg/dose IV q12h for up to 14 days; Info: switch to PO regimen ASAP to complete course

[IV route, 35-119 kg]

Dose: 200 mg IV q12h for up to 14 days; Info: switch to PO regimen ASAP to complete course

[IV route, >120 kg]

Dose: 300 mg IV q12h for up to 14 days; Info: switch to PO regimen ASAP to complete course

mpox

[PO route, <6 kg]

Dose: 50 mg PO bid x14 days; Info: for pts w/ severe dz or aberrant infection, or at high risk for severe dz; consider giving w/ cidofovir or brincidofovir; may extend duration based on clinical response; give w/in 30min after full moderate-high fat meal

[PO route, 6-12 kg]

Dose: 100 mg PO bid x14 days; Info: for pts w/ severe dz or aberrant infection, or at high risk for severe dz; consider giving w/ cidofovir or brincidofovir; may extend duration based on clinical response; give w/in 30min after full moderate-high fat meal

[PO route, 13-24 kg]

Dose: 200 mg PO bid x14 days; Info: for pts w/ severe dz or aberrant infection, or at high risk for severe dz; consider giving w/ cidofovir or brincidofovir; may extend duration based on clinical response; give w/in 30min after full moderate-high fat meal

[PO route, 25-39 kg]

Dose: 400 mg PO bid x14 days; Info: for pts w/ severe dz or aberrant infection, or at high risk for severe dz; consider giving w/ cidofovir or brincidofovir; may extend duration based on clinical response; give w/in 30min after full moderate-high fat meal

[PO route, 40-119 kg]

Dose: 600 mg PO bid x14 days; Info: for pts w/ severe dz or aberrant infection, or at high risk for severe dz; consider giving w/ cidofovir or brincidofovir; may extend duration based on clinical response; give w/in 30min after full moderate-high fat meal

[PO route, >120 kg]

Dose: 600 mg PO tid x14 days; Info: for pts w/ severe dz or aberrant infection, or at high risk for severe dz; consider giving w/ cidofovir or brincidofovir; may extend duration based on clinical response; give w/in 30min after full moderate-high fat meal

[IV route, <35 kg]

Dose: 6 mg/kg/dose IV q12h x14 days; Info: for pts w/ severe dz or aberrant infection, or at high risk for severe dz; consider giving w/ cidofovir or brincidofovir; switch to PO regimen ASAP to complete course; may extend duration based on clinical response

[IV route, 35-119 kg]

Dose: 200 mg IV q12h x14 days; Info: for pts w/ severe dz or aberrant infection, or at high risk for severe dz; consider giving w/ cidofovir or brincidofovir; switch to PO regimen ASAP to complete course; may extend duration based on clinical response

[IV route, >120 kg]

Dose: 300 mg IV q12h x14 days; Info: for pts w/ severe dz or aberrant infection, or at high risk for severe dz; consider giving w/ cidofovir or brincidofovir; switch to PO regimen ASAP to complete course; may extend duration based on clinical response

renal dosing

[PO route]

renal impairment: no adjustment

HD/PD: no adjustment; no supplement

[IV route]

CrCl <30: contraindicated; Info: risk of IV vehicle accumulation

HD/PD: contraindicated

hepatic dosing

[no adjustment]