Ayvakit

Adult Dosing .

Dosage forms:  TAB: 25 mg, 50 mg, 100 mg, 200 mg, 300 mg

Special Note

[uses, dosing may vary]

Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing including toxicity-related dose adjustments

gastrointestinal stromal tumor, unresectable or metastatic

[300 mg PO qd]

Info: for patients with platelet-derived growth factor receptor alpha (PDGFRA) exon 18 mutation, including PDGFRA D842V mutations; give >1h before or >2h after meal

systemic mastocytosis

[advanced disease]

Dose: 200 mg PO qd; Info: for patients with aggressive systemic mastocytosis, systemic mastocytosis with associated hematological neoplasm, or mast cell leukemia; not for patients with Plt <50,000; give >1h before or >2h after meal

[indolent disease]

Dose: 25 mg PO qd; Info: not for patients with Plt <50,000; give >1h before or >2h after meal

renal dosing

[see below]

CrCl >30: no adjustment; CrCl <30: not defined

HD/PD: not defined

hepatic dosing

[gastrointestinal stromal tumor]

Child-Pugh Class C: 200 mg qd

[advanced systemic mastocytosis]

Child-Pugh Class C: 100 mg qd

[indolent systemic mastocytosis]

Child-Pugh Class C: 25 mg qod

Peds Dosing .

Peds dosing is currently unavailable or not applicable for this drug.