Tukysa

Adult Dosing .

Dosage forms:  TAB: 50 mg, 150 mg

Special Note

[uses, dosing may vary]

Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing including toxicity-related dose adjustments

HER2-positive breast CA, advanced or metastatic

[300 mg PO bid]

Info: for patients who have received prior anti-HER2 based regimens; part of multi-drug regimen; do not cut/crush/chew tab

HER2-positive, RAS wild-type colorectal CA, unresectable or metastatic

[300 mg PO bid]

Info: for patients who have progressed after fluoropyrimidine-, oxaliplatin- and irinotecan-containing chemo; give with trastuzumab; do not cut/crush/chew tab

renal dosing

[see below]

CrCl >30: no adjustment; CrCl <30: not defined

HD/PD: not defined

hepatic dosing

[adjust dose amount]

Child-Pugh Class C: 200 mg bid

Peds Dosing .

Peds dosing is currently unavailable or not applicable for this drug.