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Darzalex Faspro (daratumumab/ hyaluronidase-fihj)
daratumumab/ hyaluronidase
Adult Dosing .
Dosage forms: INJ: 120 mg/2000 units per mL
Special Note
- [equivalency or interchangeability info]
- Info: not interchangeable w/ IV daratumumab
- [drug name clarification]
- Info: nonproprietary name = daratumumab/hyaluronidase-fihj
- [uses, dosing may vary]
- Info: refer to institution protocols and pkg insert prior to prescribing for uses, premeds, postmeds, prophylactic meds, and dosing incl. toxicity-related dose adjustments
multiple myeloma, newly diagnosed
- [autologous HSCT ineligible, combo w/ bortezomib, melphalan, and prednisone]
- Dose: 1800 mg/30,000 units SC qwk x6 doses, then starting wk 7, give 1800 mg/30,000 units SC q3wk x16 doses, then starting wk 55, give 1800 mg/30,000 units SC q4wk; Info: give VZV prophylaxis w/in 1wk of tx start and x3mo after D/C
- [autologous HSCT ineligible, combo w/ lenalidomide and dexamethasone]
- Dose: 1800 mg/30,000 units SC qwk x8 doses, then starting wk 9, give 1800 mg/30,000 units SC q2wk x8 doses, then starting wk 25, give 1800 mg/30,000 units SC q4wk; Info: give VZV prophylaxis w/in 1wk of tx start and x3mo after D/C
- [autologous HSCT eligible, combo w/ bortezomib, thalidomide, and dexamethasone]
- Dose: 1800 mg/30,000 units SC qwk x8 doses, then starting wk 9, give 1800 mg/30,000 units SC q2wk x4 doses for total 16wk induction tx, then upon recovery from autologous HSCT, give 1800 mg/30,000 units SC q2wk x4 doses for total 8wk consolidation tx; Info: give VZV prophylaxis w/in 1wk of tx start and x3mo after D/C
- [autologous HSCT eligible, combo w/ bortezomib, lenalidomide, and dexamethasone]
- Dose: 1800 mg/30,000 units SC qwk x8 doses, then starting wk 9, give 1800 mg/30,000 units SC q2wk x4 doses for total 16wk induction tx, then upon recovery from autologous HSCT, give 1800 mg/30,000 units SC q2wk x4 doses for total 8wk consolidation tx; Info: give VZV prophylaxis w/in 1wk of tx start and x3mo after D/C
multiple myeloma, relapsed or refractory
- [combo w/ bortezomib and dexamethasone]
- Dose: 1800 mg/30,000 units SC qwk x9 doses, then starting wk 10, give 1800 mg/30,000 units SC q3wk x5 doses, then starting wk 25, give 1800 mg/30,000 units SC q4wk; Info: for pts who have received at least 1 prior tx; give VZV prophylaxis w/in 1wk of tx start and x3mo after D/C
- [combo w/ lenalidomide and dexamethasone]
- Dose: 1800 mg/30,000 units SC qwk x8 doses, then starting wk 9, give 1800 mg/30,000 units SC q2wk x8 doses, then starting wk 25, give 1800 mg/30,000 units SC q4wk; Info: for pts who have received at least 1 prior tx; give VZV prophylaxis w/in 1wk of tx start and x3mo after D/C
- [combo w/ pomalidomide and dexamethasone]
- Dose: 1800 mg/30,000 units SC qwk x8 doses, then starting wk 9, give 1800 mg/30,000 units SC q2wk x8 doses, then starting wk 25, give 1800 mg/30,000 units SC q4wk; Info: for pts who have received at least 1 prior line of tx, incl. lenalidomide and a proteasome inhibitor; give VZV prophylaxis w/in 1wk of tx start and x3mo after D/C
- [combo w/ carfilzomib and dexamethasone]
- Dose: 1800 mg/30,000 units SC qwk x8 doses, then starting wk 9, give 1800 mg/30,000 units SC q2wk x8 doses, then starting wk 25, give 1800 mg/30,000 units SC q4wk; Info: for pts who have received 1-3 prior lines of tx; give VZV prophylaxis w/in 1wk of tx start and x3mo after D/C
- [monotherapy]
- Dose: 1800 mg/30,000 units SC qwk x8 doses, then starting wk 9, give 1800 mg/30,000 units SC q2wk x8 doses, then starting wk 25, give 1800 mg/30,000 units SC q4wk; Info: for pts who have received at least 3 prior lines of tx, incl. a proteasome inhibitor (PI) and an immunomodulatory agent (IMiD), or who are double-refractory to a PI and an IMiD; give VZV prophylaxis w/in 1wk of tx start and x3mo after D/C
light chain amyloidosis, newly diagnosed
- [combo w/ bortezomib, cyclophosphamide, and dexamethasone]
- Dose: 1800 mg/30,000 units SC qwk x8 doses, then starting wk 9, give 1800 mg/30,000 units SC q2wk x8 doses, then starting wk 25, give 1800 mg/30,000 units SC q4wk for up to 2y; Max: 2y; Info: give VZV prophylaxis w/in 1wk of tx start and x3mo after D/C
renal dosing
- [see below]
- CrCl >15: no adjustment; CrCl <15: not defined
- HD/PD: not defined
hepatic dosing
- [see below]
- mild impairment: no adjustment; moderate-severe impairment: not defined
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.